Table 5 Overrepresented functional annotations describing genes that show non-uniform variance as a function of sleep duration
From: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues
Annotation cluster 1 | Enrichment score: 14.904263431729085 | |||
|---|---|---|---|---|
Category | Term | P Value | Fold Enrichment | FDR |
SP_PIR_KEYWORDS | Microsome | 4.15E-24 | 23.74 | 5.37E-21 |
KEGG_PATHWAY | Retinol metabolism | 3.03E-20 | 17.72 | 3.19E-17 |
SP_PIR_KEYWORDS | Heme | 3.00E-19 | 15.99 | 3.89E-16 |
SP_PIR_KEYWORDS | Monooxygenase | 5.41E-19 | 19.11 | 7.00E-16 |
SP_PIR_KEYWORDS | Oxidoreductase | 1.09E-18 | 6.50 | 1.41E-15 |
KEGG_PATHWAY | Drug metabolism | 6.69E-18 | 15.30 | 7.05E-15 |
GOTERM_BP_FAT | GO:0055114 ~ oxidation reduction | 3.07E-16 | 5.27 | 5.22E-13 |
SP_PIR_KEYWORDS | Iron | 6.73E-15 | 8.04 | 8.76E-12 |
KEGG_PATHWAY | Metabolism of xenobiotics by cytochrome P450 | 7.52E-15 | 14.78 | 7.96E-12 |
KEGG_PATHWAY | Linoleic acid metabolism | 3.42E-13 | 17.46 | 3.61E-10 |
SP_PIR_KEYWORDS | endoplasmic reticulum | 4.12E-13 | 4.87 | 5.33E-10 |
KEGG_PATHWAY | Arachidonic acid metabolism | 1.33E-07 | 8.30 | 1.40E-04 |
SP_PIR_KEYWORDS | metal-binding | 4.05E-04 | 1.69 | 5.22E-01 |
Annotation Cluster 2 | Enrichment Score: 7.639984508416769 | |||
Category | Term | P Value | Fold Enrichment | FDR |
KEGG_PATHWAY | Complement and coagulation cascades | 3.36E-15 | 13.77 | 3.52E-12 |
GOTERM_BP_FAT | GO:0009611 ~ response to wounding | 2.76E-10 | 5.96 | 4.32E-07 |
GOTERM_BP_FAT | GO:0007596 ~ blood coagulation | 3.19E-08 | 14.07 | 4.99E-05 |
GOTERM_BP_FAT | GO:0050817 ~ coagulation | 3.19E-08 | 14.07 | 4.99E-05 |
GOTERM_BP_FAT | GO:0007599 ~ hemostasis | 3.63E-08 | 13.87 | 5.67E-05 |
GOTERM_BP_FAT | GO:0050878 ~ regulation of body fluid levels | 2.66E-07 | 11.06 | 4.15E-04 |
SP_PIR_KEYWORDS | blood coagulation | 1.33E-06 | 19.52 | 1.72E-03 |
GOTERM_BP_FAT | GO:0042060 ~ wound healing | 1.89E-06 | 8.79 | 2.95E-03 |
SP_PIR_KEYWORDS | Plasma | 7.60E-05 | 21.50 | 9.83E-02 |
Annotation Cluster 3 | Enrichment Score: 5.173741168245643 | |||
Category | Term | P Value | Fold Enrichment | FDR |
KEGG_PATHWAY | Steroid hormone biosynthesis | 2.85E-09 | 14.03 | 3.01E-06 |
KEGG_PATHWAY | Drug metabolism | 5.61E-09 | 13.15 | 5.92E-06 |
KEGG_PATHWAY | Androgen and estrogen metabolism | 1.09E-06 | 13.91 | 1.15E-03 |
KEGG_PATHWAY | Ascorbate and aldarate metabolism | 3.62E-06 | 22.95 | 3.82E-03 |
KEGG_PATHWAY | Pentose and glucuronate interconversions | 1.67E-04 | 16.88 | 1.76E-01 |
KEGG_PATHWAY | mmu00500:Starch and sucrose metabolism | 3.41E-04 | 9.56 | 3.59E-01 |
SP_PIR_KEYWORDS | Glycosyltransferase | 7.02E-04 | 4.67 | 9.04E-01 |