SPI | Gene | D1 | D2 | M1 | M2 | Descriptor | Role in pathogenesis |
---|---|---|---|---|---|---|---|
CS54 | ratA | - | + | + | + | Ribosome association toxin | No role in virulence [10] |
 | sivI | - | + | + | + | Outer membrane protein | No role in virulence [10] |
 | sivH | - | + | + | + | Invasin-like | Colonising peyers patch (Mouse) [10] |
SPI-1 | STM2901 | - | - | + | + | Putative cytoplasmic protein | NI [40] |
 | STM2902 | - | - | + | + | Putative cytoplasmic protein | NI [40] |
 | STM2903 | - | - | + | + | Putative cytoplasmic protein | NI [40] |
 | SC2837 | - | - | + | + | Hypothetical protein | NI [41] |
 | SC2838 | - | - | + | + | Hypothetical protein | NI [41] |
SPI-3 | Pseudo | + | + | - | - | NI | NI [42] |
 | yadC | + | + | - | - | Fimbrial like protein | |
 | yadK | + | + | - | - | Fimbrial like protein | NI [42] |
 | yadL | + | + | - | - | Fimbrial like protein | NI [42] |
 | yadN | + | + | - | - | Fimbrial like protein | NI [42] |
 | htrE | + | + | - | - | Porin/ fimbrial assembly | High temperature resistance above 50°C [44] |
 | ecpD1 | + | + | - | - | Pilin chaperone | Expressed with increasing temp above 22°C [44] |
 | ecpD2 | + | + | - | - | Pilin chaperone | NI [42] |
 | Pseudo | + | + | - | - | NI | NI [42] |
 | rhuM | - | - | + | + | Cytoplasmic protein | Epithelial migration [45] |
 | STY4039 | - | - | + | + | EnvR binding site | No role in virulence [46] |
SPI-6 | STY0296 | + | + | - | - | Hypothetical protein | No role in virulence [46] |
 | STY0300 (sirA) | - | - | + | + | Transcription factor | |
 | STY0301 (safC) | - | - | + | + | Outer membrane usher protein | Up regulated during intracellular replication [49] |
 | STY0302 (sciM) | - | - | + | + | Hemolysin-coregulated protein | NI [50] |
 | STY0303 (sciN) | - | - | + | + | Outer membrane lipoprotein | Need for Type VI secretion, biofilm formation [51] |
 | STY0307 | - | - | + | + | Hypothetical protein | NI [50] |
 | STY0311 | - | - | + | + | Mannosyl-glycoprotein | NI [50] |
 | STY0312 | - | - | + | + | Hypothetical protein | NI [50] |
 | STY0319 | - | - | + | + | Rhs-family protein | NI [50] |
 | STY0320 | - | - | + | + | Putative cytoplasmic protein | NI [50] |
 | STY0321 | - | - | + | + | Rhs1 protein | NI [50] |
 | STY0322 | - | - | + | + | Hypothetical protein | NI [50] |
 | STY0323 | - | - | + | + | Hypothetical protein | NI [50] |
 | safA | - | - | + | + | Fimibrial usher protein | |
 | Pseudo | - | - | + | + | NI | NI [46] |
 | safB | - | - | + | + | Periplasmic fimbrial chaperone protein | NI [46] |
 | safC | - | - | + | + | Outer membrane usher protein | Up regulated during intracellular replication [49] |
 | safD | - | - | + | + | Fimibrial usher protein | No effect in virulence in mice [52] |
 | STY0338 | - | - | + | + | Periplasmic binding protein | |
 | Pseudo | - | - | + | + | NI | NI [46] |
 | sinR (pagN) | - | - | + | + | HTH transcription factor | |
 | NI | + | + | - | - | Rhs-family protein | NI |
 | NI | + | + | - | - | Rhs-family protein | NI |
 | NI | + | + | - | - | Phosphotriesterase | NI |
 | NI | + | + | - | - | Hypothetical protein | NI |
 | NI | + | + | - | - | Hypothetical protein | NI |
 | orf7 (Photorhabdus ) | + | + | - | - | SinR-like, HTH transcription factor | NI [54] |
 | NI | + | + | - | - | Putative cytoplasmic protein | NI |
 | Pseudo | + | + | - | - | NI | NI |
 | Pseudo | + | + | - | - | NI | NI |
 | tcfA | + | + | - | - | Fimbrial protein | Increased expression with increased salinity, non virulence in INT-407 cells [55] |
 | tcfB | + | + | - | - | Fimbrial protein | Increased IgG-tcfB in patients with S. Typhi [56] |
 | tsaC | + | + | - | - | Fimbrial usher protein | No effect on adhesion to mice monolayers [57] |
 | tcfD | + | + | - | - | Fimbrial protein | NI [46] |
 | rnhA-dnaQ like | - | + | - | - | DNA polymerase 3 epsilon subunit ribonuclease H | NI [58] |
 | NI | - | + | - | - | Ribonuclease HI | NI |
 | gloB like | - | + | - | - | Hydroxyacylglutathione hydrolase | methylglyoxal degradation [46] |
 | mltD | - | + | - | - | Membrane-bound lytic murein transglycosylase D | Enchance virulence in Vibria anguillarum in zebrafish [59] |
 | NI | - | + | - | - | Methyltransferase UbiE/COQ5 | Ubiquinone/ menaquinone biosynthesis [60] |
 | yafD | - | + | - | - | AP like endonuclease | Egg albumen resistance [7] |
 | NI | - | + | - | - | Putative drug efflux protein | NI |
 | NI | - | + | - | - | Hypothetical oxidoreductase | NI |
 | dkgB | - | + | - | - | 2, 5 didehydrogluconate reductase B | Detoxing response to hyperosmotic solution [61] |