Figure 2

Factor and unsupervised cluster analysis of transcriptome profiles. Radiation quality was the major source of variation in the model of differential gene expression profiles in response to HZE and γ-ray radiation in normal HBEC cells. A, Sources of variation obtained from ANOVA suggested that radiation quality and post-radiation time were the major sources of variation. Error indicated the random noise level of the ANOVA model. B, Unsupervised hierarchical clustering of gene expression profiles that were normalized to mock-irradiated controls suggest distinct responses of cells to different radiation types.