Figure 1

Validation of the differences in mRNA expression between Fra-1^+/+and Fra-1^Δ/Δmice for selected microarray genes at different time points after bleomycin treatment. Lung mRNA abundance was determined by quantitative real-time RT-PCR. The graphs represent the fold change over vehicle treated Fra-1^+/+ controls after normalization with the expression of GAPDH. Results are mean ± SD for 3-4 mice in each group. ^*p<0.05, PBS vs bleomycin; ^†p<0.05, Fra-1^Δ/Δ vs Fra-1^+/+ mice.