Skip to main content

Table 3 QTLs for the macromolecular composition of different tissues in BXD RI strains

From: ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains

Tissue Chr Trait LRS Significance Increasing allele Additive Effect
Reproductive 1 total fat 13.61 * B6 198.54
Adipose   (15084) 11.92 * B6 188.92
Tissue 1 saturated fat 13.71 * B6 57.78
   (15083) 12.07 * B6 55.09
  1 unsaturated fat 13.4 * B6 1.26
   (15082) 11.76 * B6 1.20
  1 acyl chain length 13.16 * B6 0.36
   (15085) 10.82 * B6 0.36
  1 collagen 13.24 * B6 0.34
   (15089) 11.95 * B6 0.33
  1 collagen integrity 10.62 * D2 3.39
   (15090) 11.96 * D2 3.80
    11.38 * D2 3.49
  9 saturated to unsaturated ratio (15086) 10.58 * B6 1.05
  12 total fat (15084) 21.47 ** B6 236.62
  12 saturated fat (15083) 21.47 ** B6 68.65
  12 unsaturated fat (15082) 21.24 ** B6 1.51
  12 acyl chain length (15085) 16.27 * B6 0.40
  12 collagen (15089) 22.09 ** B6 0.42
  12 collagen integrity (15090) 17.65 ** D2 4.16
  12 lipid to protein ratio (15087) 20.95 ** B6 99.76
  17 lipid to protein ratio 14.27 * B6 86.64
   (15087) 13.69 * B6 85.26
Liver 5 total fat (15092) 12.49 * B6 0.30
  5 saturated fat (15091) 11.73 * B6 0.15
  9 collagen (15096) 14.48 * B6 0.10
    12.31 * B6 0.10
  9 collagen integrity (15097) 13.28 * D2 76.10
    11.69 * D2 73.89
  17 total fat (15092) 16.72 * B6 0.35
  17 saturated fat (15091) 13.84 * B6 0.17
  17 acyl chain length (15093) 12.55 * B6 1.17
  17 lipid to protein ratio 13.04 * B6 0.05
   (15094) 19.36 ** B6 0.06
  18 glycogen (15098) 10.9 * D2 0.22
Muscle 5 collagen integrity (15105) 11.72 * B6 20.77
  9 collagen (15104) 17.33 * D2 1.03
  9 collagen integrity 17.19 * B6 23.45
   15105) 16.81 * B6 23.60
  9 Glycogen (15106) 12.31 * B6 0.27
  15 collagen (15104) 11.1 * D2 0.86
  1. The degree of LRS significance was denoted as: suggestive*, significant**. Genome-wide significance (p<0.05) and suggestive (p<0.63) thresholds were calculated as likelihood ratio statistic (LRS) in linkage analyses computed for 1000 permutations [60]. The values of total, unsaturated and saturated fat, the ratio of saturated to unsaturated fat, collagen and collagen integrity, the ratio of lipid to protein and glycogen are relative values as described in experimental procedures. GeneNetwork Record ID was given in parenthesis for each trait.
\