Skip to main content

Table 3 Putative new P. falciparum gene family members of variant gene families

From: Variant surface antigens of malaria parasites: functional and evolutionary insights from comparative gene family classification and analysis

Gene family New member MP# MP % Avg. E-value Avg. PID (Stddev) Current annotation/comment
phist PF14_0744 21 9.9 0.2 27.6(5.6) Exported protein, unknown function
  PF14_0745 23 10.9 0.3 24.7(4.7) Probable protein, unknown function
  MAL8P1.205 40 18.9 0.0002 28.2(4.4) GEXP13
  PF10_0015a 88 41.5 7e-14 35.0(11.9) Carries acyl-CoA binding domain
hyp4/hyp6 PFL2560c 2 12.5 3e-15 46.3(14.4) Probably truncated pseudogene
  PFI0086w 5 31.3 0.002 29.0(3.7) Alternative start codon 40 aa downstream
  PF14_0760 4 25.0 0.2 35.7(13.2) Exported protein, unknown function
TSP_1 MAL8P1.45 48 23.3 7e-17 42.7(14.7) Conserved protein, unknown function
  PF08_0136b 24 11.7 4e-34 35.3(16.3) Von Willebrand factor A-domain related
msp-7 PF13_0192 14 46.7 0.9 25.7(4.8) Part of MSP7 gene cluster on chr13
  PF13_0194 3 10 3 28.8(3.3) Part of MSP7 gene cluster on chr13
msp-3 PF10_0351 4 14.3 4 30.4(3.8) Part of MSP gene cluster on chr10
etramp PFL0065w 2 2.8 9e-15 43.7(6.5) Conserved protein, unknown function
hyp5 PF14_0743 10 100.0 3e-5 31.4(2.5) Annotated hyp15 protein
hyp15 PFB0950w 3 100.0 3e-18 44.5(13.0) Exported protein, unknown function
hyp10 PF08_0001 1 50.0 3 34.6(0.0) Exported protein, unknown function
hyp12 MAL8P1.206 3 100.0 2e-17 47.1(4.9) Exported protein, unknown function
hyp17 PF14_0741 1 50.0 1e-198 91.2(0.0) Split gene model; merged in PlasmoDB 9.0
  1. Clusters corresponding to variant gene families were searched for P. falciparum proteins that are currently not annotated as members of these gene families. Only clusters with a Jaccard index of at least 0.6 were considered in this search (Table 1). Annotated pseudogenes and gene fragment not shown. MP # and MP% indicate number and percentage of BLAST match pairs between the putative new member and all other proteins in the cluster representing that gene family. Avg. E-value and Avg. PID denote the average E-value and the average PID of these BLAST match pairs, respectively. aUnusual phist gene family member carrying an N-terminal acyl-CoA-binding protein domain (Pfam PF00887).