Figure 5

Comparison of predicted splicing-regulated MREs from true, false, and randomly selected MREs. The left panel shows the fractions of splicing-regulated MREs contained in miRTarBase [36] and TarBase [35]. True MRE is the algorithm-predicted MRE with positive validation, and false MRE is the algorithm-predicted MRE with negative validation defined from TarBase. The right panel shows a histogram of splicing regulation predicted in MREs randomly selected from reference sequences. Data for random MREs were averages over 4,315 or 1,700 randomly selected MRE sets (100 random MREs/set), which were sampled from full-length (green) and 3′-UTR (red) sequences, respectively. P-value was computed by one-sample Wilcoxon signed-rank test.