Differential gene expression in the endometrium on gestation day 12 provides insight into sow prolificacy

BMC Genomics

Table 2 Differentially expressed genes in the endometrium that may affect sow prolificacy

Gene	Expression Level (TPM)		FDR	Function
Gene	ER	LL	FDR	Function
PTGS1	14.5	3.64	1.37E-06	− Converts arachidonic acid to PGH₂[28, 38].
				− Rate-limiting enzymes in PG synthesis [38].
				− Essential to reproduction [39–43].
PTGS2	5.22	10.92	1.20E-02	− The same as those of PTGS1.
PTGES	91.93	15.10	1.68E-12	− Converts PGH₂ to PGE₂[30].
PTGES2	25.52	9.64	8.36E-08	− Converts PGH₂ to PGE₂ [44, 45].
CBR1	1.16	0.01	1.70E-02	− Converts PGE₂ into PGF_2α[46].
CBR2	5.22	141.9	1.17E-136	− Converts PGE₂ into PGF_2α according to KEGG pathway.
RBP4	1160.03	1609.79	7.06E-67	− Transports vitamin A to the embryos [47], thereby affecting the growth and development of the embryos [48].
UF	102.37	1175.01	0.00E-00	− Transports iron to the embryos [49].
IGF1	0.58	14.01	4.99E-13	− Additively has metabolic, mitogenic and differentiation actions and are essential for prenatal growth of the conceptus [50, 51].
IGF1	0.58	14.01	4.99E-13	− Control and differentiation of the uterus for blastocyst implantation [52].
IGF2	13.92	2.18	2.83E-05	− The same as those of IGF1.
HB-EGF	0.01	1.64	3.62E-02	− Blastocyst growth, and trophoblast outgrowth [53] and development [54].
FGF7/KGF	8.70	71.31	3.07E-48	− Proliferation and differentiation of trophectoderm [55].

See Additional file 7: Table S5 for details of all the differentially expressed genes. Numbers in square brackets are the numbers of the papers in the reference list.

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