Figure 3

Transient changes in levels of Gcn5 and H3K18ac during stress adaptation at ORF are correlated for a subset of genes. A Significant overlap between gene ORFs with significantly (p < 0.05) changed Gcn5 localisation during the stress and recovery growth regime and genes ORFs with significantly (p < 0.05) changed H3K18ac (left panel) or H4K16ac (right panel) levels. The Venn diagrams show the number of overlapping and non-overlapping genes. The p-values show that the number of genes in the intersection is significantly greater than the number expected by chance. The overlapping genes (in parenthesis) are clearly overrepresented in the category of genes shorter than 1kb with p value of 1.73e-99 for the 670 intersection genes and 9.33e-45 for the 348 intersection genes after analysis by a hypogeometric test. B-D Transient reduction in the average level of Gcn5 during stress adaptation is accompanied by transient reduction in the levels of H3K18ac but not H4K16ac at ORF. The relative average levels (arbitrary units) of Gcn5 (B), H3K18ac (C), H4K16ac (C) and H3 (D) at ORF are plotted for the groups of overlapping genes defined in part A. The arbitrary units are independently defined for each of parts A-D. The number of genes in each group is shown in parenthesis. Line colors represent different samples taken during the stress and recovery growth regime.