Table 5 Upstream regulators induced by L-OHP treatment in HT-29R
Upstream regulator | Log ratio | Molecule type | Predicted activation state | z-score | p-value of overlap | Target molecules in dataset |
|---|---|---|---|---|---|---|
TGM2 | 0.968 | Enzyme | Activated | 4.762 | 8.90E-09 | DDX60, DDX60L, DEFA1, HIP1, IFI6, IFIT1, IFIT2, IFIT3, IFIT5, IRF9, MT2A, OAS3, OASL, PARP9, PHLDA1, PLSCR1, RARRES3, RUNX2, SAMD9L, SLFN5, STAT1, TGFB1, XAF1 |
STAT1 | 0.855 | Transcription regulator | Activated | 3.592 | 1.47E-08 | AGT, ALDH1A3,CLIC5, DPP4, HERC6, IFI27, IFI6, IFIT1, IFIT2, IFITM1, IRF9, ISG15, KCTD12, PSMB8, PSMB9, PTGS2, RUNX1, SLFN5, STAT1, TLR3, TYMP, USP18 |
TLR3 | 0.624 | Transmembrane receptor | Activated | 3.392 | 5.85E-07 | DHX58, IFI44, IFI44L, IFI6, IFIH1, IFIT1,IFIT2, IFIT3, IFNE, ISG15, MX1, MX2, OASL, PHLDA1, PLK2, PTGS2, STAT1, TLR3, USP18 |
INSIG1 | -2.061 | Other | Activated | 3.039 | 1.74E-06 | CXCR4, CYP51A1, DHCR7, HMGCS1, HMGCS2, IDI1, LDLR, PLD1, SCD, SQLE, SREBF1, STARD4,TGFB1 |
NFATC2 | 0.635 | Transcription regulator | Activated | 3.019 | 3.84E-05 | IFIT2, ISG15, LMO4, MX1, OASL, PLD1, PLK2, PTGS2, SH3BP5, SLCO3A1, STAT1, TGFB1,T LR3 |
IFNE | 0.861 | Cytokine | Activated | 2.804 | 2.07E-07 | IFIH1, IFIT2, MX2, PTGS2, RARRES3, STAT1, TLR3, USP18 |
PARP9 | 1.087 | Other | Activated | 2.433 | 1.24E-06 | IFI44, IFIT1, IFIT2, IFIT3, ISG15, STAT1 |
IFIH1 | 0.742 | Enzyme | Activated | 2.190 | 2.68E-04 | BST2, ISG15, MX1, PHLDA1, RND3 |
SREBF1 | -0.624 | Transcription regulator | Inhibited | -2.980 | 1.36E-07 | CAMK1D, CYP51A1, DHCR7, HMGCS1, HNF4A, IDI1, INSIG1, LDLR, MSMO1, NR0B2, PNPLA3, PTGS2, SCD, SQLE, SREBF1, STARD4,T GFB1, VEGFA |
USP18 | 0.941 | Peptidase | Inhibited | -2.219 | 5.62E-05 | IFI6, IFITM3, IRF9, ISG15, MX1 |