Figure 1

Prediction of functional association network in P. infestans. (A) Integration of four distinct data sources to predict the functional association network in P. infestans. We predicted protein-protein interactions by projection of interactions from three source organisms (yeast, human, thale cress) to P. infestans; co-expression, conservation of co-expression between P. infestans and P. sojae and phylogenetic co-occurrence in 51 species. Before the integration of the four data sources into a single network, these were scored based on their relative confidence using KEGG maps. (B) Number of orthologous groups between P. infestans and the three source organisms used for projecting physical interactions. (C) Projection of physical interactions via orthologous groups. In cases where the mapping was unclear, different genomic features such as co-expression and shared functional annotation were considered to disentangle these specific cases.