Developmental stages of the asexual lifecycle of P. infestans and determined functional modules. (A) Transition between five distinct developmental stages in the asexual lifecycle of P. infestans. Gene expression data of these stages are available  and were used to assess gene expression changes between the transitions. Transitions between different developmental stages are colored coded. (B) The gene expression changes and the membership of all 825 genes predicted in the five functional modules are displayed. The heat map shows the gene expression changes (log2) for the transitions of two subsequent life stages (same color code as in A; heat map saturated at ± 2.5). Presence (black) or absence (white) of genes in a functional module is highlighted next to the heat map and membership is indicated by color code. C refers to the sporulation module as described in (C). (C) Determined functional module of genes up-regulated during sporulation and their predicted associations. Examples discussed within the text and their directly associated proteins are highlighted with light green. The nodes are colored according to the fold change in expression in sporangia compared to hyphae (same scale as in B).