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Table 6 Gene ontology analysis of significantly over- and underrepresented genes

From: Analysis of copy number variants by three detection algorithms and their association with body size in horses

  Number of reference genes (Homo sapiens) Number of genes in CNV regions (Horse) Expected Raw p-value Bonferroni corrected p-value for multiple testing
Biological process-overrepresented genes
Response to stress 586 17 3.60 1.34E-07 2.28E-05
G-protein coupled receptor protein signaling pathway 1042 22 6.41 3.99E-07 6.82E-05
Muscle contraction 613 17 3.77 2.50E-07 4.28E-05
Sensory perception 864 13 5.31 2.65E-03 4.53E-01
Phagocytosis 101 6 0.62 4.25E-05 7.28E-03
Macrophage activation 352 8 2.16 1.58E-03 2.71E-01
Response to stimulus 1921 22 11.81 3.19E-03 5.46E-01
Cyclic nucleotide metabolic process 109 6 0.67 6.46E-05 1.10E-02
Nerve-nerve synaptic transmission 122 7 0.75 1.20E-05 2.06E-03
Synaptic transmission 756 12 4.65 2.51E-03 4.30E-01
Biological process-underrepresented genes
Cell cycle 1867 3 11.48 2.47E-03 4.22E-01
Transcription from RNA polymerase II promoter 2343 2 14.41 3.30E-05 5.64E-03
Regulation of transcription from RNA polymerase II promoter 1780 1 10.95 1.37E-04 2.33E-02
Transcription 2353 2 14.47 3.11E-05 5.31E-03
Primary metabolic process 8037 16 49.43 3.67E-11 6.28E-09
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3987 8 24.52 2.75E-05 4.70E-03
Cellular component organization 1496 2 9.20 4.22E-03 7.21E-01
Mesoderm development 1621 2 9.97 2.14E-03 3.67E-01
Proteolysis 1230 1 7.56 3.69E-03 6.30E-01
Metabolic process 8351 17 51.36 1.78E-11 3.04E-09
Protein metabolic process 3295 3 20.26 6.38E-07 1.09E-04
  1. The software PANTHER was used for the evaluation of 45 CNV regions detected by all three algorithms. In five CNV regions we could not detect any genes for evaluation.