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Figure 10 | BMC Genomics

Figure 10

From: Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele

Figure 10

DSBs are depleted in the autosomal subtelomeric regions of Gal4BD-Spo11 mice. The coverage of DSBs (top panels) and H3K4me3 (bottom panels) in the regions corresponding to the wild type hotspots was calculated in 1 Mb windows across all autosomes. Values were normalized as a percentage of total in-hotspot coverage. DSB depletion is evident at the non-centromeric (right) chromosomal ends in Gal4BD-Spo11 mice. PRDM9-dependent H3K4me3 coverage in these regions does not change from the chromosomal average. Note that the sequence of the first 3 Mb of centromeric ends (left) of mouse chromosomes is not available.

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BMC Genomics

ISSN: 1471-2164

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