The numbers and proportions of mutations that occur at nonsynonymous sites with different GERP scores for individuals in the 1000 Genomes populations. For each individual, the proportion of nonsynonymous sites carrying the minor allele that fall into each GERP score bin was found and the proportions were averaged for individuals within each population in the 1000 Genomes data (A). Similarly, the average distribution was found for each population using the absolute numbers of alleles at heterozygous (B) and homozygous derived allele (inferred from a six way primate alignment) (C) sites falling in each positive GERP bin. African populations are blue, admixed American populations are orange, European populations are red and Asian populations are green. Error bars denote 95% confidence intervals.