Figure 8

Gene network of known relationships and associations with specific cell processes for those differentially expressed genes from the top 10% of each module that also had the most neighbor connections (see Table 2for list). Node shapes code: oval and circle – protein; diamond – ligand; irregular polygon – phosphatase; circle/oval on tripod platform – transcription factor; ice cream cone – receptor. Grey rectangles represent cell processes; arrows with plus sign show positive regulation/activation, arrows with minus sign – negative regulation/inhibition. Grey arrows represent regulation, lilac – expression, green – promoter binding, olive – protein modification.