Figure 1

Limit of SNV detection. Shown is the maximal error rate ϵ at which SNVs of frequency f are detectable if d sites are analysed simultaneously. In a simple model of SNV calling (see Methods), this bound is ϵ^d < 1/[1 + (1 − f)/f] ≈ f, giving rise to the lines of slope 1/d for two haplotypes at Hamming distances d in the double logarithmic plot.