Table 2 Biological functions of the IL6-correlated genes
Gene symbol | Name | Biological functiona |
|---|---|---|
IL6 | interleukin-6 | Inflammation |
CXCL2 | chemokine (C-X-C motif) ligand 2 | Inflammation |
HBEGF | heparin-binding epidermal growth factor | Proliferation |
SERPINE1 | plasminogen activator inhibitor 1 | Motility/Adhesion |
DUSP1 | dual specificity protein phosphatase 1 | Proliferation |
ZFP36 | tristetraprolin, zinc finger protein ZFP-36 | Proliferation |
IER3 | immediate early response 3 | Proliferation |
FOSB | AP-1 , fosB | Proliferation |
NR4A1 | TR3 orphan receptor, growth factor-inducible nuclear protein N10 | Proliferation |
SOCS3 | suppressor of cytokine signaling 3, cytokine-inducible SH2 protein 3 | Inflammation |
EGR2 | early growth response protein 2 | Proliferation |
EGR3 | early growth response protein 3 | Proliferation |
SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | Metabolism |
MMP19 | matrix metalloproteinase-19 | Motility/Adhesion |
KLF4 | Krueppel-like factor 4 | Proliferation |
ATF3 | cyclic AMP-dependent transcription factor ATF-3 | Proliferation |
RGS2 | cell growth-inhibiting protein 31 , regulator of G-protein signaling 2 | Proliferation |
EGR1 | early growth response protein 1 | Proliferation |
SOD2 | manganese-containing superoxide dismutase, mitocondrial | Metabolism |
CYR61 | cysteine-rich, angiogenic inducer, 61 , IGF-binding protein 10 | Metabolism |
IL8 | interleukin 8 | Inflammation |
DUSP5 | dual specificity protein phosphatase 5 | Proliferation |
GADD45B | growth arrest and DNA damage-inducible protein GADD45 beta | Cell cycle control/Apoptosis |
TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | Inflammation |
FPR1 | formyl peptide receptor 1, N-formylpeptide chemoattractant receptor | Inflammation |
CCL3 | chemokine (C-C motif) ligand 3 | Inflammation |
GFPT2 | hexosephosphate aminotransferase 2 | Metabolism |
NAMPT | nicotinamide phosphoribosyltransferase, pre-B-cell colony-enhancing factor 1 | Metabolism |
NR4A3 | Mitogen-induced nuclear orphan receptor, Nuclear hormone receptor NOR-1 | Proliferation |
GEM | RAS-like protein KIR, GTP-binding mitogen-induced T-cell protein | Proliferation |
FOS | AP-1, c-fos | Proliferation |
PPP1R15A | growth arrest and DNA-damage-inducible 34 | Cell cycle control/Apoptosis |
CEBPD | CCAAT/enhancer-binding protein delta, Nuclear factor NF-IL6-beta | Inflammation |
THBD | thrombomodulin | Motility/Adhesion |
KLF6 | Krueppel-like factor 6 | Proliferation |
RHOB | rho-related GTP-binding protein RhoB | Proliferation |
KLF2 | Krueppel-like factor 2 | Proliferation |
IL1B | interleukin 1, beta | Inflammation |
G0S2 | G0/G1 switch regulatory protein 2 | Cell cycle control/Apoptosis |
C5AR1 | complement component 5 receptor 1 | Motility/Adhesion |
MCL1 | bcl-2-like protein 3 | Cell cycle control/Apoptosis |