Figure 4

Gene Ontology (GO) enrichments of WT and Ercc1^-/Δmice. GO analysis of the 77 overlapping regulated genes in WT and Ercc1^-/Δ glomeruli demonstrate similarities between both datasets. The lower the p-value of term enrichment the darker the bubble color. Bubble sizes reflect the frequency of a respective GO term in the GO database. The lines represent hierarchical connections between GO terms. In both conditions, we find an enrichment of terms associated with immune response, defense response, proteolysis, endocytosis, and regulation of apoptotic processes. As expected, Ercc1^-/Δ samples additionally show a significant enrichment of terms associated with cell cycle/mitosis. The interactive graph was chosen from the REVIGO server.