Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes

BMC Genomics

Table 3 Hibernation signatures, TP signatures, and AP signatures compared with calorie restriction and PPARα knockout

		TP signatures (916 genes)	AP signatures (823 genes)	Hibernation signatures (508 genes)
Calorie restriction (253 genes)	Overlap #	24	29	18
	PCC	0.41	0.23	0.58
	p-value	0.04	0.23	0.01
PPARα knockout (1587 genes)	Overlap #	123	103	73
PPARα knockout (1587 genes)	PCC	−0.19	−0.14	−0.15
	p-value	0.04	0.17	0.19

Overlap # is the number of overlapping genes. PCC is Pearson’s correlation coefficient of log2 fold-changes of overlapping genes. P-value is calculated based on Pearson's product moment correlation coefficient to test the null hypothesis (PCC = 0). TP: torpor vs. post-reproduction; AP: arousal episodes vs. post-reproduction.

ISSN: 1471-2164