Figure 5

Hypothetical scheme representing the different steps occuring during viral infection. A: Attachment. B: Membrane fusion with intervention of the actin cytoskeleton and cell adhesion proteins. C: Translocation of capside to the nucleus with Microtubules MT. D: Docking at the nuclear pore: release of viral genome into the nucleus. E: Concatemer. F: Transcription of the viral mRNA. G: Traduction of the viral mRNA in the RER for the capsid proteins and maturation in the Golgi for the envelope proteins. H: Replication. I: Capsid formation. J: Budding to the inner nuclear membrane followed by release of the capsid into the cytoplasm. K: Envelopment of Trans Golgi network vesicule with proteins to form the envelope. L: Fusion of the vesicule with the virion to the plasma membrane to ensure releasing of the mature virion. M and N: hijacking cellular machinery.