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Table 1 ECM, adhesion, and matrix remodeling genes affected by FGF2 treatment

From: FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts

Symbol

Name

Log2 fold change

Fold change

Adjusted p-value

ECM

Collagens

COL21A1

Collagen, type XXI, alpha 1

2.99

7.97

4.40E-06

COL14A1

Collagen, type XIV, alpha 1

2.25

4.74

3.58E-05

COL13A1

Collagen, type XIII, alpha 1

1.62

3.07

0.003150228

COL18A1

Collagen, type XVIII, alpha 1

1.40

2.64

0.026150843

COL6A3

Collagen, type VI, alpha 3

1.02

2.02

0.026527481

COL10A1

Collagen, type X, alpha 1

0.61

1.52

0.033185205

COL27A1

Collagen, type XXVII, alpha 1

−0.59

−1.50

0.000481652

COL16A1

Collagen, type XVI, alpha 1

−0.86

−1.82

0.000501675

COL1A2

Collagen, type I, alpha 2

−0.92

−1.90

0.001062514

COL12A1

Collagen, type XII, alpha 1

−1.16

−2.23

0.001285122

COL5A1

Collagen, type V, alpha 1

−1.17

−2.25

0.000370081

COL1A1

Collagen, type I, alpha 1

−1.26

−2.40

2.50E-05

COL15A1

Collagen, type XV, alpha 1

−1.40

−2.64

6.04E-06

COL8A1

Collagen, type VIII, alpha 1

−1.92

−3.77

5.23E-08

COL5A2

Collagen, type V, alpha 2

−1.99

−3.96

0.000570978

COL5A3

Collagen, type V, alpha 3

−2.24

−4.72

8.97E-06

COL4A4

Collagen, type IV, alpha 4

−2.34

−5.07

0.001283892

COL4A2

Collagen, type IV, alpha 2

−2.40

−5.28

3.02E-14

COL11A1

Collagen, type XI, alpha 1

−4.27

−19.37

4.50E-12

COL4A1

Collagen, type IV, alpha 1

−4.61

−24.43

3.58E-05

Laminins

LAMA5

Laminin, alpha 5

1.74

3.35

5.24E-06

LAMB1

Laminin, beta 1

0.68

1.60

0.026626565

LAMA4

Laminin, alpha 4

0.66

1.58

0.030288975

LAMA3

Laminin, alpha 3

0.62

1.54

0.033413419

LAMC2

Laminin, gamma 2

−0.78

−1.72

0.001416011

LAMA2

Laminin, alpha 2

−0.81

−1.76

0.048073235

LAMB2

Laminin, beta 2 (laminin S)

−0.88

−1.84

0.016068977

LAMC1

Laminin, gamma 1 (formerly LAMB2)

−1.34

−2.53

8.56E-05

Fibronectins

FNDC4

Fibronectin type III domain containing 4

1.27

2.41

0.000256057

FNDC3A

Fibronectin type III domain containing 3A

0.81

1.75

0.036705362

FNDC3B

Fibronectin type III domain containing 3B

−1.12

−2.17

0.001723239

FN1

Fibronectin 1

−1.14

−2.20

0.00019286

FNDC1

Fibronectin type III domain containing 1

−4.06

−16.64

2.29E-12

Adhesion molecules

Integrins

ITGA2

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

3.69

12.92

4.74E-06

ITGA10

Integrin, alpha 10

2.62

6.14

3.90E-07

ITGB3

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

2.37

5.16

8.55E-05

ITGB1

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

−1.66

−3.15

6.42E-06

ITGBL1

Integrin, beta-like 1 (with EGF-like repeat domains)

−2.31

−4.97

6.78E-08

ITGB2

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

−3.34

−10.15

0.000457236

Cadherins

CDHR3

Cadherin-related family member 3

1.22

2.33

0.008261441

PCDHGC3

Protocadherin gamma subfamily C, 3

1.21

2.32

0.007298787

PCDH9

Protocadherin 9

1.19

2.29

0.001804197

PCDH10

Protocadherin 10

1.08

2.11

0.00089387

CDH11

Cadherin 11, type 2, OB-cadherin (osteoblast)

−0.72

−1.64

0.025796984

PCDHB2

Protocadherin beta 2

−0.76

−1.69

0.010987526

CDH2

Cadherin 2, type 1, N-cadherin (neuronal)

−2.05

−4.14

1.11E-05

PCDH7

Protocadherin 7

−2.36

−5.12

0.002357001

Matrix remodeling

MMP1

Matrix metallopeptidase 1 (interstitial collagenase)

4.37

20.61

8.28E-12

ADAMTS8

ADAM metallopeptidase with thrombospondin type 1 motif, 8

3.31

9.94

1.65E-10

MMP27

Matrix metallopeptidase 27

1.90

3.72

4.70E-06

MMP10

Matrix metallopeptidase 10 (stromelysin 2)

1.81

3.52

0.000118221

MMP3

Matrix metallopeptidase 3 (stromelysin 1, progelatinase)

1.81

3.51

7.05E-06

TIMP4

TIMP metallopeptidase inhibitor 4

1.53

2.88

0.000259942

ADAM15

ADAM metallopeptidase domain 15

1.04

2.06

0.000703266

ADAMTSL4

ADAMTS-like 4

0.83

1.77

0.040463485

MMP11

Matrix metallopeptidase 11 (stromelysin 3)

0.82

1.76

0.009142377

ADAMTSL1

ADAMTS-like 1

0.68

1.60

0.024404628

THBS2

Thrombospondin 2

−0.60

−1.52

0.033809806

ADAM19

ADAM metallopeptidase domain 19

−0.82

−1.77

0.016522395

TIMP3

TIMP metallopeptidase inhibitor 3

−1.48

−2.78

8.49E-06

ADAM12

ADAM metallopeptidase domain 12

−2.72

−2.23

1.30E-08

ADAMTS1

ADAM metallopeptidase with thrombospondin type 1 motif, 1

−3.06

−8.32

4.12E-08

ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5

−3.99

−15.84

0.000108412