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Figure 12 | BMC Genomics

Figure 12

From: PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

Figure 12

PRE mutant designs. TESS predictions of transcription factor binding sites (Table 1) were used to design oligomers for deleting one or more putative transcription factor binding sites in the PRE. A. Wildtype PRE sequence with all target sites indicated by rectangles corresponding to TF positions. B-H. Mutant oligomers with specific target sites indicated by rectangles corresponding to TF positions. TF sites introduced by mutagenesis have boldface and underlined names. Specific base mutations indicated by boldface and underline in sequences.

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BMC Genomics

ISSN: 1471-2164

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