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Table 6 Analysis of APP proximal promoter region multiple sequence alignment

From: PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

 

n

PRE

PuF site

  

Ric

Homologyd

Ri

Homology

Primates

9

49.04±3.81

95.1%±1.7%

11.31±0.93

98.2%±2.4%

Euarchontoglires

18

48.48±3.02

92.8%±1.8%

11.35±0.49

92.5%±4.2%

Boreoeutheria

27

50.58±1.50

93.2%±1.6%

11.72±0.27

92.1%±4.2%

Eutheria

32

50.29±1.29

90.8%±1.9%

11.19±0.23

91.5%±4.5%

Mammals

35

39.36±2.85

76.6%±2.8%

8.64±0.48

73.8%±6.2%

  1. cRi: Information content/specificity ± 95% confidence interval.
  2. dHomology: Average percent ± 95% confidence interval.
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BMC Genomics

ISSN: 1471-2164

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