The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

Table 5 A. actinomycetemcomitans infection-enriched GO terms in the epididymal AT transcriptome

GO category	Enriched GO term	Go term p-value^a	GO term-associated gene products
GO category	Enriched GO term	Go term p-value^a	Up-regulated^b	Down-regulated^b
GO:0003823	Antigen binding	<0.001	Igk-C, LOC100047788	-
GO:0019731	Antibacterial humoral response	0.002	LOC100047788	-
GO:0019730	Antimicrobial humoral response	0.002	LOC100047788	-
GO:0016064	Immunoglobulin mediated immune response	0.004	LOC100047788	Bcl6
GO:0032787	Monocarboxylic acid metabolic process	0.006	Pcx, Insig1, Elovl6, Scd2	-
GO:0006633	Fatty acid biosynthetic process	0.006	Insig1, Elovl6, Scd2	-
GO:0019216	Regulation of lipid metabolic process	0.012	Cidea, Insig1, Thrsp	-
GO:0002455	Humoral immune response mediated by circulating immunoglobulin	0.013	LOC100047788	-
GO:0045833	Negative regulation of lipid metabolic process	0.015	Cidea, Insig1	-
GO:0005515	Protein binding	0.022	Slc15a2, Cidea, Thrsp, Elovl6, Lrtm1, Igk-V5, LOC384413, LOC637227, Insig1, LOC100047162, LOC669053, Igk-C, LOC100047628, LOC100047788, Ighg, Ighg3, LOC676136	Bcl6, Itga11
GO:0006641	Triglyceride metabolic process	0.027	Thrsp, Insig1	-
GO:0046890	Regulation of lipid biosynthetic process	0.032	Thrsp, Insig1	-
GO:0009611	Response to wounding	0.034	Fabp4, Klf6	Chst4, Bcl6
GO:0001816	Cytokine production	0.045	Fabp4, Cidea	Bcl6
GO:0001818	Negative regulation of cytokine production	0.046	Cidea	Bcl6
GO:0051973	Positive regulation of telomerase activity	0.048	9130213B05Rik	-
GO:0042938	Dipeptide transport	0.048	Slc15a2	-
GO:0006954	Inflammatory response	0.049	Fabp4	Chst4, Bcl6

^aP-values are corrected for multiple hypotheses using Benjamini-Hochberg false discovery rate.
^bFold change limit 2.0.
Number of biological replicates is 3.
GO, gene ontology. The maximum of 20 GO categories is shown.

ISSN: 1471-2164