Table 3 Fold change differences in gene expression in M. bovis field isolates 1121, 2451 and 1307 compared to 2122
Mb CDS | Mtb CDS | Common | 1121/01 | 2451/01 | 1307/01 | Product | Assoc. SNP/InDel | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  | 7h9 | RPMI | 4hr MØ | 24 hr MØ | 7h9 | RPMI | 4hr MØ | 24 hr MØ | 7h9 | RPMI | 4hr MØ | 24 hr MØ |  |  |
Mb0038c | Rv0037c |  |  |  |  |  |  | 4↑ | 3↑ | 3↑ |  |  |  |  | probable conserved integral membrane protein |  |
Mb0124c | Rv0120c | fusA2 |  |  |  |  | 3↑ |  |  |  | 3↑ |  |  |  | probable elongation factor |  |
Mb0258 | Rv0252 | nirB |  |  |  |  |  |  |  |  | 9↑ | 12↑ | 21↑ | 9↑ | nitrite reductase (large subunit) | sSNP at postn. 303227 in 1307/01 only; C-T; |
Mb0259 | Rv0253 | nirD |  |  |  |  |  |  |  |  |  | 3↑ | 4↑ | 5↑ | nitrite reductase (small subunit) |  |
Mb0428c | Rv0420c |  |  |  |  |  |  |  |  |  |  |  |  | 2↑ | possible transmembrane protein |  |
Mb0734 | Rv0713 |  |  |  |  |  |  |  | 2↑ |  |  |  |  |  | probable conserved transmembrane protein |  |
Mb0947c | Rv0923c |  |  |  |  |  | 2↓ |  |  |  | 2↓ |  |  |  | conserved hypotheitical protein |  |
Mb0948c | Rv0924c | mntH | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | cation uptake system | Â |
Mb1013; Mb1014 | Rv0987 |  |  |  |  |  | 5↑ | 10↑ | 5↑ |  | 5↑ | 7↑ | 6↑ |  | probable adhesion component transport ABC transporter | nSNP at postn. 1104263 in 2451/01 and 1307/01; A-G (STOP to W); sSNP at postn 1103991 in 2451/01 and 1307/01 |
Mb1015 | Rv0988 |  |  |  |  |  | 3↑ | 9↑ |  |  | 3↑ | 5↑ | 5↑ |  | possible conserved exported protein |  |
Mb1161 | Rv1130 |  |  |  |  |  |  |  |  |  |  |  |  | 2↓ | conserved hypothetical protein |  |
Mb1162 | Rv1131 | gltA1 |  |  |  |  | 3↓ |  |  |  |  |  |  |  | probable citrate synthase |  |
Mb1554c | Rv1527c | pks5 |  |  | 2↓ |  |  |  |  |  |  |  |  |  | probable polyketide synthase |  |
Mb1562 | Rv1535 |  |  | 2↑ |  |  |  |  |  |  |  | 5↑ |  |  | hypothetical protein |  |
Mb1619c | Rv1593c |  |  |  |  | 2↑ |  |  |  |  |  |  |  |  | conserved hypothetical protein |  |
Mb1749c | Rv1720c |  |  |  |  |  |  |  |  |  | 10↑ | 19↑ | 18↑ | 12↑ | conserved hypothetical protein | nSNP at postn. 1932704 in 1307/01 only ; C-T (G to D) |
Mb1750c | Rv1721c |  |  |  |  |  |  |  |  |  | 6↑ | 3↑ | 9↑ | 5↑ | conserved hypothetical protein |  |
Mb1833c | Rv1804 |  |  |  |  |  |  |  |  |  |  |  |  | 3↓ | conserved hypothetical protein |  |
Mb1834c | Rv1805c |  |  |  |  |  |  |  |  |  |  | 4↑ |  |  | hypothetical protein |  |
Mb1835 | Rv1806 | PE20 |  |  |  |  |  |  |  |  |  | 3↑ |  |  | PE family protein |  |
Mb1885c | Rv1854c | ndh |  |  |  |  |  |  |  |  |  |  |  | 3↓ | probable nadh dehydrogenase |  |
Mb1914c | Rv1882c |  |  |  |  |  |  | 6↑ | 3↑ | 6↑ |  |  |  |  | probable short-chain type dehydrogenase/reductase | sSNP at postn 2122970 in 2415/01 only: C-T |
Mb2007c | Rv1985c |  |  |  |  |  |  |  |  |  | 4↑ | 3↑ | 3↑ |  | probable transcriptional regulatory protein | nSNP at postn. 2208296 in 1307/01 only; G-A (Q to Stop) |
Mb2015c | RV1992c | ctpG |  |  |  | 2↓ |  |  |  |  |  |  |  | 3↓ | probable cation transporter |  |
Mb2420c | Rv2398c | cysW |  |  |  |  |  | 2↓ |  |  |  | 6↓ |  |  | sulphate transporter |  |
Mb2421c | Rv2399c | cysT |  |  |  |  |  | 2↓ |  |  |  | 4↓ |  |  | sulphate transporter |  |
Mb2607 | Rv2577 |  |  |  |  |  | 9↓ | 5↓ | 7↓ | 12↓ | 10↓ | 7↓ | 7↓ | 13↓ | conserved hypothetical protein [first part] |  |
Mb3194 | Rv3169 |  |  |  |  |  |  |  |  |  | 3↑ | 3↑ | 2↑ | 3↑ | conserved hypothetical protein |  |
Mb3477c | Rv3447c |  |  |  |  |  | 8↓ |  | 3↓ | 10↓ | 9↓ | 2↓ |  | 7↓ | probable conserved membrane protein | nSNP at postn. 3812465 in 2451/01 and 1307/01; T-C (S to G) |
Mb3563c | Rv3533c | PPE62 |  |  |  |  | 5↑ | 5↑ |  |  |  |  |  |  | ppe family protein |  |
Mb3721c | Rv3696c | glpK |  |  |  |  |  |  |  |  |  |  | 3↓ |  | glycerol kinase |  |
Mb3803 | Rv3774 | echA21 |  |  |  |  |  | 8↑ | 7↑ | 22↑ |  |  |  |  | possible enoyl-coA hydratase | sSNP at postn. 4155803 in 2415/01 only; G-A |