Figure 5
From: Global regulatory architecture of human, mouse and rat tissue transcriptomes
Dendrogram representing an example where expression profiling facilitates determination of functionally related genes. Across the tissue profiles, the gene homologs 21_2_h, 21_4_m, 21_5_r clustered together while 21_1_h as well as 21_3_m were more distant. On the sequence level alone, 21_1_h and 21_3_m had higher similarity to the rat homolog 21_5_r than the other human and mouse homologs. This example shows how combining gene expression profiles with sequence similarity helps in assigning correct mappings for functionally related genes.