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Figure 2 | BMC Genomics

Figure 2

From: Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression

Figure 2

Investigating the impact of WSTF loss on the human Xi. (a) Distribution of XIST RNA in RPE1 and BAZ1B -/- using a direct-labeled RNA FISH probe (green). Nuclei in all images are counterstained with DAPI (blue), merged images are shown on the right of each group of three images, and white arrowheads indicate the location of the Xi. (b) Examples of the distribution of markers that are elevated at the Xi territory including H3K9me3 (green), H3K27me3 (green) and mH2A1 (red), and those that are underrepresented; H3K4me2 (green) and H3K9Ac (green). (c) Examples of elevated levels of BRCA1, γ-H2A.X and SNF2H at the Xi (red). SNF2H was never observed enriched at the Xi BAZ1B -/-.

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BMC Genomics

ISSN: 1471-2164

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