Figure 4

Function and pathway analysis identified by IPA associated with targets genes. Functional analysis for targets genes, which got from by combining the predicted target gene result by IPA software for differentially expressed miRNAs (fold change ≥ 2, P< 0.05) with the mRNA expression profile result (GSE NO.GSE28204, mRNA fold change ≥ 1.5, P< 0.05). (A): The 10 most significant function directory across the entire dataset, and across multiple datasets, y-axis displays the significance. For the ratio, taller bars have more genes associated with the canonical pathway than shorter bars. (B) The 10 most significant canonical pathways across the entire dataset, and across multiple datasets, y-axis displays the significance. For the ratio, taller bars have more genes associated with the canonical pathway than shorter bars.