Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

Schupp, Michael; Chen, Fang; Briggs, Erika R; Rao, Shilpa; Pelzmann, Helmut J; Pessentheiner, Ariane R; Bogner-Strauss, Juliane G; Lazar, Mitchell A; Baldwin, Don; Prokesch, Andreas

doi:10.1186/1471-2164-14-758

Table 2 Fold difference in expression (fasted/fed) of transcripts regulated in WAT, LIV, and SM by fasting

From: Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

UNIQID	NAME	WAT	LIV	SM	UNIQID	NAME	WAT	LIV	SM
NM_029083	Ddit4	7.86	4.46	17.72	NM_133904	Acacb	2.74	−2.05	1.40
NM_007669	Cdkn1a	2.02	10.20	4.43	NM_024479	Wbscr27	1.48	−1.43	2.02
NM_007679	Cebpd	3.36	2.29	8.54	NM_016972	Slc7a8	2.03	−1.72	1.74
NM_010220	Fkbp5	3.40	5.84	4.19	NM_019873	Fkbpl	−1.33	1.33	2.03
BC096647	E230001N04Rik	2.50	4.54	5.11	NM_008580	Map3k5	1.51	1.72	−1.40
NM_183187	Fam107a	3.96	3.56	3.27	NM_172648	Ifi205	1.66	−1.95	2.03
NM_008817	Peg3	6.05	2.53	2.10	NM_133748	Insig2	1.61	1.48	−1.36
NM_010559	Il6ra	2.91	2.16	4.47	NM_009104	Rrm2	−1.39	1.65	1.47
NM_016693	Map3k6	3.06	2.05	3.96	NM_009653	Alas2	1.65	−1.49	1.53
NM_027560	Arrdc2	2.74	1.65	4.48	NM_027442	Ddo	1.65	1.31	−1.33
NM_018881	Fmo2	2.51	3.18	2.75	NM_133955	Rhou	1.38	−1.50	1.70
NM_001159367	Per1	2.51	3.17	2.66	NM_010197	Fgf1	−1.33	1.47	1.37
NM_011704	Vnn1	4.48	1.78	1.96	NM_001081401	Adamts3	1.48	1.38	−1.38
NM_139306	Acer2	4.07	1.38	2.58	NR_004446	Gm7035	1.49	−1.52	1.49
NM_001077348	Plin5	2.06	2.76	3.15	NM_028595	Ms4a6c	1.41	−1.53	1.40
NM_029415	Slc10a6	2.74	1.89	3.31	NM_029620	Pcolce2	1.32	−1.40	1.33
NM_133765	Fbxo31	3.71	2.46	1.60	NM_001081317	Anubl1	1.44	−1.68	1.32
NM_201256	Eif4ebp3	3.08	3.18	1.34	NM_029494	Rab30	−1.37	3.28	−1.63
NM_001033324	Zbtb16	1.54	3.91	2.02	NM_027868	Slc41a3	−1.58	3.50	−2.49
NM_030166	Galntl2	3.09	1.63	2.67	NM_008063	Slc37a4	−1.38	1.93	−1.36
ENSMUST00000059018	1110003O08Rik	3.57	2.31	1.46	NM_029967	Adamtsl1	1.53	−1.34	−1.34
NM_013602	Mt1	1.79	3.05	2.41	NM_177471	Ccdc69	1.61	−1.34	−1.45
ENSMUST00000039517	Syde2	4.10	1.60	1.51	NM_026250	Zh2c2	−1.30	1.41	−1.37
NM_009994	Cyp1b1	3.19	1.46	2.35	NM_178111	Trp53inp2	−1.63	1.36	−1.39
NM_001013780	Slc25a34	1.83	2.19	2.98	NM_009255	Serpine2	−1.67	1.58	−1.60
NM_011817	Gadd45g	2.53	2.33	2.07	NM_001005341	Ypel2	1.39	−1.50	−1.61
NM_010706	Lgals4	2.49	2.68	1.69	NM_177351	C630028N24Rik	−1.96	1.39	−1.37
NM_011366	Sorbs3	1.92	2.14	2.62	NM_026524	Mid1ip1	−1.97	−2.03	1.81
NM_011977	Slc27a1	2.27	2.99	1.35	NM_011943	Map2k6	−2.14	1.68	−2.20
NM_015763	Lpin1	1.83	2.87	1.59	NM_027950	Osgin1	−1.84	−3.45	2.46
NM_025404	Arl4d	1.58	1.84	2.84	ENSMUST00000100735	Gm10387	−1.68	1.59	−2.85
NM_153574	Fam13a	2.93	1.71	1.50	ENSMUST00000111704	Rassf8	−1.31	−1.31	−1.47
NM_001113283	BC031353	2.44	1.95	1.67	NM_011063	Pea15a	−1.32	−1.45	−1.36
ENSMUST00000095691	Gm9766	1.56	1.57	2.88	BC016078	4931406C07Rik	−1.33	−1.35	−1.47
NM_001077364	Tsc22d3	2.23	2.24	1.53	NM_172928	Dclk3	−1.53	−1.32	−1.30
NM_144907	Sesn2	2.50	1.72	1.64	NM_025901	Polr3k	−1.40	−1.40	−1.36
BC019494	Fam134b	2.28	1.48	1.97	NM_016701	Nes	−1.39	−1.39	−1.45
NM_001004468	Tacc2	1.75	1.48	2.32	NM_028651	Tmtc4	−1.47	−1.41	−1.36
NM_001081005	1500012F01Rik	1.85	1.51	2.19	NM_009448	Tuba1c	−1.35	−1.66	−1.32
NM_001037709	Rusc2	1.59	1.72	2.02	NM_026102	Daam1	−1.46	−1.31	−1.57
NM_026646	Slc25a22	1.34	1.52	2.26	NM_025972	Naaa	−1.52	−1.31	−1.54
NM_001033238	Cblb	1.60	1.43	2.08	NM_008150	Gpc4	−1.71	−1.32	−1.35
NM_001033352	Klhl21	1.94	1.41	1.74	NM_019440	Irgm2	−1.58	−1.39	−1.42
NM_133670	Sult1a1	1.71	1.45	1.91	NM_183180	Tspan18	−1.53	−1.36	−1.49
NM_009760	Bnip3	1.57	1.80	1.69	ENSMUST00000108947	Gm14403	−1.34	−1.60	−1.46
NR_002840	Gas5	1.53	1.36	2.17	NM_001037170	Tomm40l	−1.69	−1.46	−1.31
NM_023184	Klf15	1.62	1.56	1.80	NM_011654	Tuba1b	−1.34	−1.72	−1.39
NM_029166	Uhrf1bp1l	1.94	1.54	1.48	NM_001111110	Cmah	−1.46	−1.49	−1.55
NM_153075	Catsper2	1.46	2.18	1.31	NM_178607	Rnf24	−1.70	−1.39	−1.45
NM_007876	Dpep1	1.71	1.78	1.44	NM_009829	Ccnd2	−1.40	−1.53	−1.66
BC150711	AI607873	1.56	1.38	1.98	NM_007486	Arhgdib	−1.52	−1.69	−1.40
NM_023635	Rab27a	1.33	1.60	2.00	NM_026740	Slc46a1	−1.99	−1.32	−1.33
NM_030697	Kank3	1.70	1.61	1.60	NM_011505	Stxbp4	−1.38	−1.44	−1.82
NM_001001883	Hecw2	1.86	1.62	1.38	NM_028372	Mblac2	−1.63	−1.58	−1.44
NM_019765	Clip1	1.45	1.39	2.02	NM_001080707	Gpr155	−1.82	−1.34	−1.52
ENSMUST00000077293	Gm5785	1.38	1.67	1.79	NM_025855	Echdc1	−1.47	−1.96	−1.32
NM_146085	Apbb3	1.52	1.54	1.79	NM_026170	Ergic1	−1.93	−1.34	−1.49
NM_133865	Dclre1b	1.76	1.41	1.64	NM_009388	Tkt	−1.65	−1.57	−1.55
NM_001081417	Chd7	1.31	2.01	1.46	NM_007984	Fscn1	−1.71	−1.58	−1.49
NM_022331	Herpud1	1.67	1.56	1.55	NM_133871	Ifi44	−1.66	−1.70	−1.44
NR_027965	2310061J03Rik	1.79	1.49	1.48	NM_152804	Plk2	−1.78	−1.41	−1.66
NM_020253	Nrxn2	1.87	1.53	1.33	NM_024257	Hdhd3	−1.73	−1.56	−1.59
AK051045	Snhg1	1.51	1.39	1.79	NM_008538	Marcks	−1.80	−1.52	−1.57
NM_001033528	Usp36	1.37	1.42	1.89	NM_178389	Gale	−1.73	−1.89	−1.31
NM_175480	Zfp612	1.65	1.56	1.41	NM_008788	Pcolce	−1.64	−1.65	−1.67
NM_011728	Xpa	1.50	1.45	1.62	NM_178079	Pm20d1	−1.97	−1.44	−1.56
NM_197986	Tmem140	2.36	−1.33	3.52	NM_145545	Gbp6	−1.87	−1.68	−1.48
NM_007705	Cirbp	1.42	1.79	1.34	NM_178869	Ttll1	−1.92	−1.40	−1.75
NM_194342	Unc84b	1.55	1.39	1.58	NM_013867	Bcar3	−2.20	−1.41	−1.47
NM_144788	Hectd1	1.35	1.36	1.80	NM_007934	Enpep	−2.15	−1.48	−1.47
NM_012050	Omd	1.38	1.72	1.39	NM_010357	Gsta4	−1.74	−1.71	−1.66
NM_026159	Retsat	1.35	1.59	1.53	XR_030785	Gm7172	−1.73	−1.68	−1.77
NM_027468	Cpm	1.77	1.37	1.31	NM_008209	Mr1	−2.38	−1.51	−1.33
NM_019713	Rassf1	1.52	1.33	1.55	NM_021273	Ckb	−2.12	−1.64	−1.50
NM_013863	Bag3	1.42	1.55	1.42	NM_009825	Serpinh1	−2.03	−1.51	−1.76
NM_199299	Phf15	1.34	1.43	1.56	NM_010260	Gbp2	−1.87	−1.68	−1.76
NM_026929	Chac1	3.69	−1.68	2.22	XR_030619	LOC100044416	−1.90	−1.72	−1.70
NM_026448	Klhl7	1.49	1.31	1.43	NM_018734	Gbp3	−2.11	−1.37	−1.87
ENSMUST00000052189	B230317F23Rik	1.40	1.38	1.43	NM_009425	Tnfsf10	−1.79	−1.40	−2.19
NM_026493	Cspp1	1.35	1.35	1.49	NM_008695	Nid2	−2.25	−1.61	−1.55
NM_001081101	4933407H18Rik	1.47	1.36	1.33	NM_009930	Col3a1	−1.70	−1.79	−1.93
NM_001033208	Gcom1	1.50	1.34	1.32	NM_020282	Nqo2	−2.08	−1.75	−1.61
NM_198020	Trmt1	1.46	1.33	1.31	NM_010700	Ldlr	−2.41	−1.60	−1.55
NM_026160	Map1lc3b	1.41	1.34	1.34	NM_007631	Ccnd1	−1.40	−2.12	−2.31
NM_138953	Ell2	1.35	1.41	1.31	ENSMUST00000071723	Akap2	−2.75	−1.44	−1.78
NM_009349	Inmt	3.33	−1.74	2.47	NM_054098	Steap4	−2.77	−1.67	−1.59
NM_183288	Sh3d20	1.31	1.37	1.35	NM_025558	Cyb5b	−2.68	−1.84	−1.59
NM_019861	Ctsf	1.35	1.33	1.32	NM_025436	Sc4mol	−1.81	−3.09	−1.38
NM_178873	Adck2	1.32	1.32	1.31	NM_007856	Dhcr7	−1.96	−2.81	−1.72
NM_026779	Mocos	1.37	−1.37	3.29	NM_011498	Bhlhe40	−2.09	−1.41	−3.05
NM_010442	Hmox1	1.48	−1.47	2.74	NM_011923	Angptl2	−1.80	−1.47	−3.30
NM_007521	Bach2	1.90	−1.34	2.16	NM_027249	Tlcd2	−3.24	−2.08	−1.42
NM_009346	Tead1	2.60	1.35	−1.47	NM_011579	Tgtp	−2.17	−1.95	−2.95
BC049153	2610024B07Rik	2.63	1.30	−1.55	NM_010255	Gamt	−5.02	−1.73	−1.53
NM_026433	Tmem100	−1.98	2.32	2.03	NM_145360	Idi1	−2.57	−4.38	−1.43
NM_018760	Slc4a4	2.22	1.49	−1.36	NM_053078	D0H4S114	−3.72	−2.12	−2.57
AY140896	LOC433762	−1.42	2.09	1.60	NM_011480	Srebf1	−3.01	−3.85	−1.56
NM_023617	Aox3	2.38	−1.53	1.40	NM_007988	Fasn	−3.01	−2.69	−3.32
NM_010831	Sik1	1.83	−1.56	1.92	NM_009270	Sqle	−2.49	−5.00	−1.77
NM_025638	Gdpd1	2.11	1.37	−1.40	NM_009128	Scd2	−9.70	−1.81	−2.40

Genes with >1.3x change (FDR5) in all investigated tissues.

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Genomics

Contact us