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Table 1 Top-5 over-represented GO/Biological process terms in exonic repeat-associated genes by species

From: Repeat-encoded poly-Q tracts show statistical commonalities across species

Saccharomyces cerevisiae
GO term E-value Term description
GO:0050789 2.35E-06 regulation of biological process
GO:0060255 8.91E-06 regulation of macromolecule metabolic process
GO:0050794 9.14E-06 regulation of cellular process
GO:0019222 9.40E-06 regulation of metabolic process
GO:0048522 1.49E-05 positive regulation of cellular process
Arabidopsis thaliana
GO term E-value Term description
GO:0016070 7.32E-10 RNA metabolic process
GO:0090304 1.59E-09 nucleic acid metabolic process
GO:0044260 1.78E-09 cellular macromolecule metabolic process
GO:0009889 2.61E-09 regulation of biosynthetic process
GO:0043170 2.74E-09 macromolecule metabolic process
Caenorhabditis elegans
GO term E-value Term description
GO:0007265 2.22E-08 Ras protein signal transduction
GO:0046578 7.32E-08 regulation of Ras protein signal transduction
GO:0050794 1.29E-07 regulation of cellular process
GO:0009966 5.92E-07 regulation of signal transduction
GO:0051056 1.11E-06 regulation of small GTPase mediated signal transduction
Drosophila melanogaster
GO term E-value Term description
GO:0048856 5.57E-106 anatomical structure development
GO:0048731 3.19E-100 system development
GO:0007275 8.55E-95 multicellular organismal development
GO:0032502 9.65E-95 developmental process
GO:0048513 1.10E-90 organ development
Mus musculus
GO term E-value Term description
GO:0032502 3.76E-45 developmental process
GO:0007399 4.92E-42 nervous system development
GO:0007275 2.98E-41 multicellular organismal development
GO:0048856 2.61E-39 anatomical structure development
GO:0048869 3.83E-39 cellular developmental process
Homo sapiens
GO term E-value Term description
GO:0007399 1.15E-20 nervous system development
GO:0030030 5.48E-16 cell projection organization
GO:0032989 6.39E-16 cellular component morphogenesis
GO:0048666 2.81E-15 neuron development
GO:0000902 3.76E-15 cell morphogenesis
  1. Note that for Drosophila melanogaster, Mus musculus and Homo sapiens, the top-5 terms are development-related, yet many regulation-related terms appear at statistically significant levels (not shown).