A systems biology approach using metabolomic data reveals genes and pathways interacting to modulate divergent growth in cattle

Table 4 Significantly enriched biological processes within the gene-gene interaction network, estimated by GO term enrichment analyses using PANTHER 8.0

Biological process	N reference*	N network (observed)^§	N network (expected)^#	P value⁺
Cell communication	1982	347	271	8.60E-06
Signal transduction	1865	325	255	5.25E-05
Cellular process	2742	450	375	6.33E-05
Cell surface receptor signaling pathway	893	169	122	1.45E-03
Cell adhesion	638	126	87	3.97E-03

*Total number of genes in the reference list for the respective biological process.
§Total number of genes in the gene-gene interaction network for the respective biological process.
#Total number of number of genes that would be expected by chance.
+Significance of enrichment calculated by a binomial statistical test and corrected for multiple testing via a Bonferroni correction.

ISSN: 1471-2164