Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain

Liu, Wei; Xiao, Shaobo; Li, Mao; Guo, Shaohua; Li, Sha; Luo, Rui; Feng, Zhixin; Li, Bin; Zhou, Zhemin; Shao, Guoqing; Chen, Huanchun; Fang, Liurong

doi:10.1186/1471-2164-14-80

Table 1 Complete list of "168-L-specific" genetic variations in CDSs

From: Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain

168-L gene	168-L gene product	Variation	168 Locus	Effect on 168-L coding
MHP168L_010	Putative uncharacterized protein	SNV	MHP168_010	L368A substitution
MHP168L_014	Fructose-bisphosphate aldolase	Deletion+SNV	MHP168_014	N-terminal deletion+SNV
MHP168L_020	ABC transporter ATP-binding protein	Deletion	MHP168_020	264-aa deletion
MHP168L_022	Putative uncharacterized protein	SNV	MHP168_022	S22S substitution
MHP168L_030	Topoisomerase IV subunit A	SNV	MHP168_030	K140E substitution
MHP168L_033	Predicted protein	Deletion	MHP168_033	N-terminal deletion
MHP168L_035	hypothetical protein	SNV	MHP168_035	K177R,A221T substitution
MHP168L_058	Glycyl-tRNA synthetase	SNV	MHP168_058	P226P substitution
MHP168L_064	hypothetical protein	SNV	MHP168_064	Y552H substitution
MHP168L_065	Predicted protein	Deletion	MHP168_065	Frameshift out 20aa
MHP168L_066	hypothetical protein	Insertion+SNV	MHP168_066	Frameshift out 42aa; F324S substitution
MHP168L_069	Chaperone protein dnaK	SNV	MHP168_069	P407P substitution
MHP168L_084	Amino acid permease	SNV	MHP168_084	R13K,T396A substitution
MHP168L_085	NADH oxidase	Insertion+SNV	MHP168_085	"TG" insertion; stop; 5aa truncation; E395G substitution
MHP168L_086	Thymidine phosphorylase	SNV	MHP168_086	V15F substitution
MHP168L_103	Outer membrane protein-P95	SNV	MHP168_103	Stop;149-aa truncation
MHP168L_105	ATP-dependent protease binding protein	SNV	MHP168_105	I159I substitution
MHP168L_110	Protein p97, cilium adhesin	SNV	MHP168_110	SNV in repeat region
MHP168L_114	50S ribosomal protein L2	SNV	MHP168_114	A2A substitution
MHP168L_127	50S ribosomal protein L15	SNV	MHP168_127	E95K substitution
MHP168L_142	Phosphopentomutase	SNV	MHP168_142	N8I substitution
MHP168L_152	ribulose-phosphate 3-epimerase	Deletion+SNV	MHP168_152	I211F substitution
MHP168L_167	L-lactate dehydrogenase	SNV	MHP168_167	N204D substitution
MHP168L_168	Hexosephosphate transport protein	SNV	MHP168_168	Q122S substitution
MHP168L_182	Putative uncharacterized protein	Deletion	MHP168_182	Frameshift;105-aa truncation
MHP168L_186	Pyruvate dehydrogenase E1-alpha subunit	SNV	MHP168_186	S194G substitution
MHP168L_187	Adenine phosphoribosyltransferase	SNV	MHP168_188	534-aa N-terminal extension
MHP168L_198	Protein P102	SNV	MHP168_198	L677L substitution
MHP168L_209	ABC transporter ATP-binding protein	SNV	MHP168_209	K258E substitution
MHP168L_212	Oligopeptide transport system permease protein	SNV	MHP168_212	P203S substitution
MHP168L_235	Putative ICEF Integrative Conjugal Element-II	SNV	MHP168_235	G192E substitution
MHP168L_243	Serine hydroxymethyltransferase	Insertion	MHP168_243	No change
MHP168L_264	ISMHp1 transposase	SNV	MHP168_264	S232P,C229R substitution
MHP168L_275	lipoate-protein ligase A	SNV	MHP168_275	A179T substitution
MHP168L_284	Cobalt import ATP-binding protein cbiO 1	SNV	MHP168_284	K64E substitution
MHP168L_289	Cation-transporting P-type ATPase	SNV	MHP168_289	E100D substitution
MHP168L_308	putative ABC transporter ATP-binding protein	SNV	MHP168_308	T708A,M700L substitution
MHP168L_311	Putative uncharacterized protein	SNV	MHP168_311	D266E substitution
MHP168L_312	Putative uncharacterized protein	Insertion+SNV	MHP168_312	Insertion;R49R,I247L substitution
MHP168L_314	Putative uncharacterized protein	Insertion+deletion	MHP168_314	Stop;14-aa truncation
MHP168L_322	hypothetical protein	Insertion	MHP168_322	Frameshift;5-aa truncation
MHP168L_345	Predicted protein	Deletion	MHP168_345	Frameshift;53-aa truncation
MHP168L_355	Putative uncharacterized protein	Insertion	MHP168_355	21-aa N-terminal deletion
MHP168L_361	hypothetical protein	SNV	MHP168_361	L265L substitution
MHP168L_377	Putative uncharacterized protein	SNV	MHP168_377	E407K substitution
MHP168L_378	P60-like lipoprotein	SNV	MHP168_378	S143N substitution
MHP168L_379	HIT-like protein	SNV	MHP168_379	D58N substitution
MHP168L_381	hypothetical protein	Insertion	MHP168_381	Frameshift
MHP168L_386	P37-like ABC transporter substrate-binding lipoprotein	Insertion	MHP168_386	Frameshift out 84aa
MHP168L_389	Putative membrane lipoprotein	SNV	MHP168_389	A265S substitution
MHP168L_392	lipoprotein	SNV	MHP168_392	T6M substitution
MHP168L_394	ABC transporter permease protein	SNV	MHP168_394	A492G substitution
MHP168L_400	Ribonuclease III	SNV	MHP168_400	V58I substitution
MHP168L_401	Putative uncharacterized protein	Deletion	MHP168_401	Frameshift out 133aa
MHP168L_409	Putative type III restriction-modification system: methylase	Deletion	MHP168_409	Frameshift out 171aa
MHP168L_412	ISMHp1 transposase	SNV	MHP168_412	G50V substitution
MHP168L_413	ABC transporter ATP-binding protein	SNV	MHP168_413	D118Y substitution
MHP168L_423	Putative uncharacterized protein	SNV	MHP168_423	Y18S substitution
MHP168L_424	Lppt protein	SNV	MHP168_424	L814F substitution
MHP168L_434	hypothetical protein	SNV	MHP168_434	W107C substitution
MHP168L_444	Putative uncharacterized protein	SNV	MHP168_444	V123A substitution
MHP168L_445	Putative uncharacterized protein	Deletion	MHP168_445	3-aa deletion in repeat region
MHP168L_454	Putative uncharacterized protein	Insertion+SNV	MHP168_454	L423I substitution
MHP168L_455	Predicted protein	Deletion+SNV	MHP168_455	59-aa extension;P51P substitution
MHP168L_456	Putative uncharacterized protein	SNV	MHP168_456	substitution
MHP168L_457	Putative uncharacterized protein	Insertion+deletion+SNV	MHP168_457	Frameshift;substitution
MHP168L_462	ABC transporter ATP-binding protein	SNV	MHP168_462	V219L substitution
MHP168L_463	ABC transporter permease protein	SNV	MHP168_463	Amino acid substitution
MHP168L_473	hypothetical protein	Insertion	MHP168_473	Frameshift out 84aa
MHP168L_482	Phosphoenolpyruvate protein phosphotransferase	SNV	MHP168_482	E562G substitution
MHP168L_490	hypothetical protein	Insertion	MHP168_490	Stop;114-aa truncation
MHP168L_498	Putative uncharacterized protein	SNV	MHP168_498	D137E substitution
MHP168L_503	P216 surface protein	Insertion	MHP168_503	Q repeat insertion
MHP168L_504	P159 membrane protein	SNV	MHP168_504	G403D,L375S, G240A substitution
MHP168L_505	YX1	SNV	MHP168_505	V175I substitution
MHP168L_506	Putative uncharacterized protein	SNV	MHP168_506	N16N substitution
MHP168L_507	asparagine synthetase A	SNV	MHP168_507	I85M substitution
MHP168L_510	Oligopeptide transport system permease protein	SNV	MHP168_510	S19S substitution
MHP168L_523	Xylose ABC transporter ATP-binding protein	SNV	MHP168_523	S8S substitution
MHP168L_531	Putative uncharacterized protein	Deletion+SNV	MHP168_531	Amino acid substitution
MHP168L_541	Predicted protein	SNV	MHP168_541	L50L substitution
MHP168L_557	Potassium uptake protein	SNV	MHP168_557	D69Y substitution
MHP168L_558	Potassium uptake protein	SNV	MHP168_558	H425Y,N477D substitution
MHP168L_559	hypothetical protein	SNV	MHP168_559	D1236G substitution
MHP168L_567	hypothetical protein	SNV	MHP168_567	D68N substitution
MHP168L_571	hypothetical protein	Insertion+deletion+SNV	MHP168_571	Frameshift;amino acid substitution
MHP168L_573	Putative uncharacterized protein	Deletion+SNV	MHP168_573	Amino acid substitution;N-terminal extension
MHP168L_576	ISMHp1 transposase	SNV	MHP168_576	Amino acid substitution
MHP168L_589	Membrane nuclease, lipoprotein	SNV	MHP168_589	S98S substitution
MHP168L_596	Glycerol-3-phosphate dehydrogenase	SNV	MHP168_596	L155V substitution
MHP168L_600	ABC transporter ATP binding protein	SNV	MHP168_600	P1014L,P1037L substitution
MHP168L_606	hypothetical protein	Deletion+SNV		Frameshift;amino acid substitution
MHP168L_614	ABC transporter xylose-binding lipoprotein	SNV	MHP168_614	I51V substitution
MHP168L_621	hypothetical protein	SNV	MHP168_621	G87G substitution
MHP168L_631	ABC transporter ATP-binding-Pr1	SNV	MHP168_631	R60W substitution
MHP168L_638	Putative uncharacterized protein	Insertion+SNV	MHP168_638	K insertion in K repeat region;K7K substitution
MHP168L_639	5'-nucleotidase precursor	SNV	MHP168_639	E411K substitution
MHP168L_666	Ribosomal RNA small subunit methyltransferase G	Deletion	MHP168_666	Frameshift out 12aa
MHP168L_668	Prolipoprotein p65	SNV	MHP168_668	T138A substitution
MHP168L_671	XAA-PRO aminopeptidase	SNV	MHP168_671	G321G substitution
MHP168L_672	Putative uncharacterized protein	SNV	MHP168_672	E104E substitution
MHP168L_673	Putative uncharacterized protein	SNV	MHP168_673	I52K,E127K substitution
MHP168L_675	hypothetical protein	SNV	MHP168_675	Y175D substitution
MHP168L_676	P146 adhesin like-protein, p97 paralog	Insertion+SNV	MHP168_676	Q insertion in PQ repeat region;S404S,W404R substitution
MHP168L_688	Putative uncharacterized protein	SNV	MHP168_688	K48N substitution
MHP168L_698	hypothetical protein	SNV	MHP168_698	R126G,V159G substitution
MHP168L_707	hypothetical protein	Insertion	MHP168_707	"F" insertion
MHP168L_747	hypothetical protein	Insertion+deletion+SNV	MHP168_091	N repeat insertion;39-aa N-terminal extension;SNV
MHP168L_748	Protein P102	Deletion+SNV	MHP168_108	Stop;782-aa truncation;SNV
MHP168L_749	Putative type III restriction-modification system: methylase	Deletion	MHP168_730	N-terminal deletion
MHP168L_750	hypothetical protein	Deletion	MHP168_435	Frameshift
MHP168L_r002	16S ribosomal RNA	SNV	MHP168_r002	Amino acid substitution
MHP168L_t027	tRNA-Ser	SNV	MHP168_t027	Amino acid substitution

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ISSN: 1471-2164

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