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Table 2 Function of common elements obtained from the high temperature stress experiment and the low oxygen stress experiment

From: Transcriptional responses to temperature and low oxygen stress in Atlantic salmon studied with next-generation sequencing technology

Gene symbol Gene product Temperature effect Metabolic function Protein function
ADK Adenosine kinase Up ATP/ITP metabolism ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives
BTD Biotinidase Up Biotin metabolism Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation
CREB3L3 cAMP responsive element binding protein 3-like 3 Up Transcription regulation Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes
CYP1A Cytochrome P450, family 1, subfamily A Up Monooxygenase activity Oxidization of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
GSTA1 Glutathione S-transferase alpha 1 Up Glutathione metabolic process Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
KNG1 Kininogen 1 Up Inflammatory response Multiple function, high molecular weight kininogen (HMWK) involved in blood coagulation
RPL10 Ribosomal protein L10 Up Translation Component of the large 60S ribosomal subunit
RPL19 Ribosomal protein L19 Up Translation Component of the large 60S ribosomal subunit
RPL3 Ribosomal protein L3 Up Translation Component of the large 60S ribosomal subunit
TSTD1 Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 Up Tumorigenesis? Highly expressed in liver, possible role in tumorigenesis
BTF3 Basic transcription factor 3 Down Regulation of transcription Required for the initiation of transcription
CPN1 Carboxypeptidase N, polypeptide 1 Down Proteolysis Protects the body from potent vasoactive and inflammatory peptides released into the circulation
EIF3C/EIF3CL Eukaryotic translation initiation factor 3, subunit C/-like Down Initiation of protein synthesis Component of the eukaryotic translation initiation factor 3
H2AFV H2A histone family, member V Down Nucleosome assembly Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
HTRA1 High-temperature requirement A serine peptidase 1 Down Regulation of cell growth/proteolysis Serine protease with a variety of targets. Regulates the availability of insulin-like growth factors (IGFs)
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase) Down Mitochondrial electron transport, NADH to ubiquinone Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase
PABPC1 Poly(A) binding protein, cytoplasmic 1 Down mRNA polyadenylation May be involved in cytoplasmic regulatory processes of mRNA metabolism
PNP Purine nucleoside phosphorylase Down Nucleobase-containing compound metabolic process Catalyze phosphorolysis of purine nucleosides
PSAP Prosaposin Down Lipid metabolic process Catabolism of glycosphingolipids with short oligosaccharide groups