Figure 3

Gene fusions identified in the TCGA Illumina HiSeq paired-end data and the Ivy Center SOLiD single-end data. This Circos plot shows all the curated fusions identified in TCGA dataset. Fusions are represented by arcs. The thickness of the arc represents the number of fusion-spanning reads. The colors of the arc represent the likely mechanism of the fusion formation. Green arcs represent fusions formed by focal amplifications, cyan arcs represent fusions formed by tandem duplications, magenta arcs represent deletion-based fusions, dark orange arcs represent fusions formed by complex genomic rearrangements and blue arcs show the fusions formed by inter-chromosomal rearrangements. The outer ring shows the fusion breakpoint density histogram at a given genomic location. Yellow triangles represent the fusions detected in the Ivy Center samples. The size of the triangle indicates the number of breakpoints in that location. The two rings outside of the ideogram show frequency of the copy number gain and loss in TCGA samples. Two major genomic hotspots for fusions can be observed on chromosomes 7 (7p11) and 12 (12q14-15). These regions also show frequent focal gains.