Figure 3

The effects of CYP2S1 depletion on retinoic acid metabolism. A simplified version of genes involved in retinol metabolism, focusing specifically on RA synthesis from retinol and retinal, RA metabolism through P450 oxidation and glucuronide conjugation, and RA signaling through either PPAR or RAR mediated pathways. Grey indicates no significant change in expression. Gold represents very low expression (i.e. base mean average value is <1.5). Shades of red and blue indicate a significant (p < 0.05) increase and decrease in expression in CYP2S1 depleted cells, respectively. Numerical values represent fold change in RNA-seq. * indicates the significant (p < 0.05).