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Table 2 Cytochrome P450s altered in CYP2S1 depleted cells

From: A transcriptomic approach to elucidate the physiological significance of human cytochrome P450 2S1 in bronchial epithelial cells

Altered in CYP2S1 depleted BEAS-2B Fold change & p value Substrate status Evidence for endogenous substrate metabolism
CYP2S1 -3.2; p < 0.0001 Orphan Retinoic acid [6, 21, 22]; prostaglandin metabolism [9, 23]
CYP1A1 -3.6; p < 0.05 Xenobiotic Estrogen, bilirubin, melatonin, arachidonic acid. Reviewed in [33]
CYP4Z1 4.2; p ≤ 0.05 Orphan Saturated and unsaturated fatty acid hydroxylation including lauric acid (C12:0, myristic acid (C14:0); 11,14-eicosadienoic acid (C20:2); (C20:4) [31]
CYP4F11 2.7; p ≤ 0.001 Orphan Fatty Acids (w-2,-3, -4, -5) [25, 32]
CYP2J2 3.6; p < 0.05 Fatty Acid Arachidonic acid epoxidation to epoxyeicosatrienoic acids (EETS). Reviewed in [34]