A transcriptomic approach to elucidate the physiological significance of human cytochrome P450 2S1 in bronchial epithelial cells

Table 2 Cytochrome P450s altered in CYP2S1 depleted cells

Altered in CYP2S1 depleted BEAS-2B	Fold change & p value	Substrate status	Evidence for endogenous substrate metabolism
CYP2S1	-3.2; p < 0.0001	Orphan	Retinoic acid [6, 21, 22]; prostaglandin metabolism [9, 23]
CYP1A1	-3.6; p < 0.05	Xenobiotic	Estrogen, bilirubin, melatonin, arachidonic acid. Reviewed in [33]
CYP4Z1	4.2; p ≤ 0.05	Orphan	Saturated and unsaturated fatty acid hydroxylation including lauric acid (C12:0, myristic acid (C14:0); 11,14-eicosadienoic acid (C20:2); (C20:4) [31]
CYP4F11	2.7; p ≤ 0.001	Orphan	Fatty Acids (w-2,-3, -4, -5) [25, 32]
CYP2J2	3.6; p < 0.05	Fatty Acid	Arachidonic acid epoxidation to epoxyeicosatrienoic acids (EETS). Reviewed in [34]

ISSN: 1471-2164