Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae

Table 3 Categories that were significantly enriched in the dataset of common genes from our study and the study performed by Teng et al.[45] and whose elimination increases the susceptibility to acetic acid and heat

Category	p-value	Number of genes in the dataset	Number of genes in the category
Biological Process
Mitochondrial translation [GO:0032543]	1.511E-07	12	88
Translation [GO:0006412]	2.893E-07	22	318
Mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	8.644 E-04	3	10
Positive regulation of mitochondrial translation [GO:0070131]	1.539 E-03	3	12
Negative regulation of peptidase activity [GO:0010466]	2.353 E-03	2	4
Mitochondrial respiratory chain complex III biogenesis [GO:0097033]	2.353 E-03	2	4
tRNA aminoacylation for protein translation [GO:0006418]	5.078 E-03	4	35
Ion transport [GO:0006811]	5.634 E-03	7	107
Deoxyribonucleotide biosynthetic process [GO:0009263]	5.728 E-03	2	6
Aerobic respiration [GO:0009060]	7.419 E-03	5	61
Chromatin modification [GO:0016568]	7.919 E-03	7	114

In the study of Teng et al.[45] a heat ramp stress was applied to the strains of Saccharomyces cerevisiae gene knockout collection, after which samples were plated in 96 spots and incubated at 30°C for 18 hours for colony visualization. Microscopic colonies were then assessed by automated counting [45].

ISSN: 1471-2164