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Figure 1 | BMC Genomics

Figure 1

From: An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury

Figure 1

Workflow of TF and miRNA regulatory network inference. Starting with TFs and miRNAs that are correlated (blue profile) or anti-correlated (red profile) with a coexpressed gene cluster (black profile), sequential steps in this workflow illustrate how multiple types of experimental and computational information are integrated in regulatory network construction. In each intermediate step, nodes and interactions identified from earlier steps are placed in the background. Circles: TFs. Hexagons: miRNAs. Blue nodes: TFs or miRNAs that are correlated with the coexpressed gene cluster. Red nodes: TFs or miRNAs that are anti-correlated with the coexpressed gene cluster. Grey nodes: master TF or miRNA regulators of coexpressed genes.

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BMC Genomics

ISSN: 1471-2164

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