Figure 9
Biased usage of incoherent and coherent feedforward loops in the SC injury response network. Feedforward loops are divided into four categories according to the expression pattern of its target gene: I1: an incoherent loop regulating myelination genes, I2: an incoherent loop regulating proliferation genes, C1: a coherent loop regulating myelination genes, and C2: a coherent loop regulating proliferation genes. For each category, the number of network motifs in the SC injury response network and the number of TFs, miRNAs, and targets that participate in those motifs are shown, with more prevalent network motifs highlighted in grey. Circles: TFs. Hexagons: miRNAs. Rectangles: target mRNAs. Blue nodes: genes or miRNAs correlated with myelination gene clusters. Red nodes: genes or miRNAs correlated with proliferation gene clusters. Arrowed edges: activation by TFs. T-shaped edges: repression by TFs or miRNAs.