Genetic dissection of blood lipid traits by integrating genome-wide association study and gene expression profiling in a porcine model

Table 2 Summary of the chromosomal regions associated with blood lipids at the genome-wide significance level

Trait	population	Top SNPs	Num. of SNP^a	Position (bp)^b	Phenotypic variance (%)^c	P-value	candidate gene^d
TC	F₂	ASGA0016328	2	SSC3: 124,769,847	7.60	2.03 × 10^-7	APOB
	Sutai	MARC0101455	3	SSC2: 56,469,735	9.75	4.40 × 10^-8	CRTC1, CERS1
	Sutai	DIAS0002715	4	SSC2: 70,246,409	8.83	5.76 × 10^-8	SMARCA4, LDLR
	Sutai	ALGA0109254	1	SSC5: 3,550,340	13.34	2.05 × 10^-7	Undetected
LDL-C	F₂	ASGA0090960	1	SSC1: 63,541,683	11.66	2.69 × 10^-8	Undetected
	F₂	ASGA0016328	3	SSC3: 124,769,847	9.80	1.90 × 10^-10	APOB
	Sutai	M1GA0002939	15	SSC2: 60,318,677	16.27	8.27 × 10^-11	CRTC1, SLC27A1, CERS1
	Sutai	DIAS0002715	25	SSC2: 70,246,409	14.26	1.17 × 10^-12	SMARCA4, LDLR,
HDL-C/LDL-C	Sutai	MARC0002082	1	SSC2: 76265092	7.34	4.43 × 10^-7	GNA11, ABCA7

^a.The number of genome-wide significant SNPs within the QTL regions.
^b.Positions of the top SNPs on the Sus Scrofa Build 10.2 assembly.
^c.Phenotypic variance explained by the top SNPs.
^d.The candidate genes were searched from annotated genes with functional relevance to serum lipids in an interval of 5.0 Mb centered at the top SNP at each significant locus. Undetected, no apparent candidate gene was detected in the corresponding genomic locus.

ISSN: 1471-2164