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Table 7 Biological processes common in keratinocytes and other cell types

From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor

 

Gene ontology process

Keratinocytes

HeLa

 

MCF10A

 

HUVEC

 

MCF7

  
  

EGF1&4hUP

GSE6783_1hUP

4 h UP

GSE6784_1hUP

4 h UP

GSE10778_1hUP

6 h UP

GSE13009_1hUP

4 h UP

48 h DN (!)

a*

regulation of gene expression

2.27E-05

8.60E-07

5.40E-10

9.30E-07

7.98E-07

1.34E-07

1.42E-04

1.50E-12

2.22E-14

2.18E-04

regulation of transcription

7.87E-05

9.91E-08

2.90E-10

1.48E-06

3.52E-07

1.42E-09

4.16E-06

3.00E-11

1.71E-13

5.94E-05

regulation of RNA metabolic process

8.79E-03

1.64E-05

3.38E-08

1.44E-04

8.88E-05

1.83E-06

3.71E-04

1.47E-09

1.83E-11

3.06E-03

regulation of transcription

1.33E-02

1.15E-04

2.32E-08

1.43E-04

9.91E-05

3.02E-07

8.11E-05

8.37E-09

1.32E-10

1.23E-03

regulation of transcription

1.59E-02

2.54E-05

1.99E-09

7.78E-04

1.41E-02

4.72E-06

4.61E-06

4.42E-06

6.28E-05

2.24E-03

positive regulation of gene expression

3.33E-02

9.78E-01

4.61E-03

1.24E-04

6.09E-05

2.04E-04

1.67E-01

2.38E-02

2.64E-04

1.19E-01

positive regulation of transcription

9.37E-02

6.97E-01

2.09E-03

1.51E-04

5.38E-05

2.25E-04

8.84E-02

2.47E-02

1.73E-04

7.71E-02

b

regulation of signal transduction

1.41E-07

3.63E-03

1.89E-03

6.60E-05

2.12E-04

1

1

9.89E-07

1.93E-04

1

signal transduction

3.62E-05

7.57E-02

6.05E-07

7.21E-11

4.10E-08

1

1

3.49E-10

4.23E-17

1

positive regulation of signal trans.

3.47E-03

2.41E-01

3.57E-03

4.67E-03

6.83E-02

1

1

1.39E-01

6.02E-01

1

response to external stimulus

2.35E-03

4.06E-01

1

8.03E-07

2.10E-01

1

1

1

1

1

negative regulation of signaling

9.10E-05

1

1

1

8.38E-01

1

1

1

1

1

c

regulation of cell motion

1.45E-07

2.89E-02

4.73E-04

1.24E-02

5.93E-04

1

1

3.63E-04

6.91E-03

5.47E-01

regulation of cell migration

6.33E-05

1.23E-02

6.66E-03

5.19E-02

1.44E-03

1

1

2.50E-04

3.01E-03

1

positive regulation of cell motility

6.15E-04

2.41E-01

2.63E-02

6.38E-01

1

1

1

5.45E-03

7.82E-03

1

positive regulation of chemotaxis

2.38E-04

9.30E-02

2.13E-03

1

1

1

1

5.00E-01

4.97E-02

1

positive regulation of cell migration

4.30E-03

1.40E-01

9.60E-03

1

1

1

1

1.64E-03

1.73E-03

1

cell motion

3.70E-03

1.13E-01

7.39E-02

4.32E-01

2.75E-01

1

1

1

6.20E-01

1

d

regulation of cell proliferation

1.65E-07

6.74E-03

1.76E-03

2.75E-03

6.40E-02

1

1

8.19E-04

1.59E-03

1

positive regulation of cell proliferation

1.64E-03

4.97E-02

9.70E-04

8.01E-03

1.51E-01

1

1

8.50E-03

4.71E-01

1

e

negative regulation of prog. cell death

6.27E-04

1.86E-02

1.25E-03

1.58E-04

2.33E-04

1

4.82E-01

5.84E-02

2.87E-03

1

regulation of apoptosis

8.12E-04

6.24E-02

8.43E-05

3.80E-07

2.73E-06

1

8.22E-02

4.64E-03

4.10E-05

1

negative regulation of apoptos

3.07E-03

6.10E-02

2.80E-03

1.22E-04

4.83E-04

1

4.05E-01

4.69E-02

2.05E-03

1

positive regulation of metabolism

4.70E-03

4.24E-02

5.71E-04

2.01E-05

6.52E-09

1.68E-03

1

4.33E-04

4.40E-07

3.26E-03

regulation of catalytic activity

7.77E-02

6.24E-01

2.05E-04

2.31E-03

1.41E-06

1

1.41E-03

1.36E-04

2.64E-05

1

cell communication

4.12E-05

7.24E-02

2.42E-06

3.87E-11

9.10E-07

1

1

2.48E-09

1.97E-15

1

phosphate metabolic process

1.08E-02

4.54E-02

4.48E-06

1.12E-02

2.46E-04

1

1

5.72E-06

2.70E-06

1

response to stress

6.39E-05

8.57E-02

5.22E-02

2.15E-07

7.26E-07

3.42E-02

1

1

1

1

anatomical structure development

5.71E-02

1

2.87E-01

2.01E-02

1

1

1

1

5.53E-02

1

transforming growth factor beta pathway

8.47E-02

1.19E-01

1

4.14E-01

1

4.44E-03

1

1

1

2.94E-01

positive regulation of leukocycytes

1.40E-02

1

5.51E-01

2.75E-01

1

1

1

9.41E-02

1

1

cell adhesion

8.83E-03

1

1

5.33E-04

1

1

1

1

1

1

transmembrane receptor protein

1.49E-02

4.44E-01

1

8.14E-02

1

6.97E-02

1

1

1

1

response to wounding

8.17E-04

1

1

2.40E-05

2.37E-01

1

1

1

1

1

regulation of cell adhesion

3.01E-03

1

1

7.25E-05

6.46E-02

1

1

1

1

1

negative regulation of DNA binding

9.91E-02

1

1

1

1

1

1

1

1

3.53E-01

biological process

5.84E-07

1.83E-04

3.12E-14

3.61E-13

9.62E-15

6.34E-09

1.21E-07

1.43E-15

1.38E-21

3.52E-02

protein metabolic process

5.42E-02

1

1.54E-06

4.66E-04

6.72E-06

1.27E-06

8.12E-02

2.46E-05

5.42E-08

6.91E-01

 

EGF 24&48 h UP

        

48 h DN (!)

biological process

1.32E-02

1.83E-04

3.12E-14

3.61E-13

9.62E-15

6.34E-09

1.21E-07

1.43E-15

1.38E-21

1.08E-06

 

metabolic process

3.16E-02

1

4.33E-12

4.76E-05

2.73E-13

5.14E-15

6.13E-12

2.61E-05

2.83E-11

1.41E-07

  1. The rightmost column shows the antiparallel overlap, i.e., with the genes suppressed by EGF in MCF7 cells. * Letters a – e indicate the fully or largely redundant biological processes.
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