Figure 1From: A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohortsGenome-wide association scan. Graphic presenting association results from (a) stage I, (b) stage II and (c) two-stage combined case and control samples. The analysis with each of the three datasets was done using Method 1 (black circles), 2 (red circles) and 3 (blue circles) accordingly. The red horizontal dashed lines indicate the Bonferroni significance threshold of P value 1.1 × 10-7 (a) and 1.5 × 10-4 (b and c). The triangle at the bottom of (a) is the estimated linkage disequilibrium structure for the 44 most significant SNPs listed in Table 2. The diamonds and squares in (a) illustrates the SNPs at which the bootstrap posterior probability for genetic association are either > 80% or within 60 ~ 80%.Back to article page