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Table 4 Parameters and results of scheme b simulation

From: A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts

Pop.

p (1)

q (1)

D (1)

p (2)

q (2)

D (2)

Population 1

Population 2

Admixed samples

M 1

M 2

M 3

M 1

M 2

M 3

M 1

M 2

M 3

1

0.40

0.10

0.00

0.70

0.10

0.00

0.1

0.0

0.0

1.6

0.0

0.0

1.2

0.0

25.3

2

0.45

0.10

0.00

0.70

0.10

0.00

0.0

0.0

0.0

1.0

0.0

0.0

0.6

0.0

12.6

3

0.50

0.10

0.00

0.70

0.10

0.00

0.3

0.0

0.0

1.4

0.0

0.0

1.2

0.0

3.7

4

0.55

0.10

0.00

0.70

0.10

0.00

0.2

0.0

0.0

2.1

0.0

0.0

1.1

0.0

0.9

5

0.60

0.10

0.00

0.70

0.10

0.00

0.0

0.0

0.0

1.1

0.0

0.0

1.0

0.0

0.3

6

0.65

0.10

0.00

0.70

0.10

0.00

0.1

0.1

0.1

0.9

0.0

0.0

0.5

0.0

0.0

7

0.40

0.10

0.00

0.50

0.10

0.02

0.1

0.0

0.0

94.3

44.8

45.6

91.1

2.9

50.8

8

0.45

0.10

0.00

0.50

0.10

0.02

0.0

0.0

0.0

93.4

45.7

47.2

90.8

1.4

28.4

9

0.40

0.10

0.02

0.50

0.10

0.00

99.5

93.9

94.7

1.1

0.0

0.0

99.4

70.1

90.0

10

0.45

0.10

0.02

0.50

0.10

0.00

99.7

95.4

95.5

1.1

0.0

0.0

99.3

69.3

77.4

11

0.40

0.10

0.02

0.50

0.10

0.02

99.6

95.0

95.1

93.2

43.7

45.7

100.0

99.7

100.0

12

0.45

0.10

0.02

0.50

0.10

0.02

99.6

95.2

95.6

93.1

47.5

49.0

100.0

99.7

100.0

13

0.40

0.10

0.02

0.50

0.10

-0.02

99.4

95.1

95.3

92.2

45.6

47.0

100.0

4.2

6.1

14

0.45

0.10

0.02

0.50

0.10

-0.02

99.1

93.9

94.0

94.2

45.8

47.8

100.0

3.0

1.4

  1. Population genetic parameters defining two genetically divergent populations and empirical statistical powers of Methods 1–3 (M 1–3) for detecting significance of linkage disequilibrium between a polymorphic marker and a putative disease locus. The empirical power was calculated from 1,000 repeated samples of 1,000 cases and 1,000 controls as the proportion of the test statistic surpassing the Bonferroni threshold 5 × 10-5. The admixed samples were made up of 57% cases and 76% controls from Population 1 and the rest from Population 2.