Table 2 Top canonical pathways generated by Ingenuity Pathway Analysis (IPA)
| Â | Ingenuity canonical pathways | p-value | Ratio | Molecules |
|---|---|---|---|---|
A | TREM1 signaling | 2.71 × 10-11 | 1.69 × 10-1 | IL8, CXCL3, ICAM1, CD40, GRB2, IL10, TLR8, CASP1, IL1B, FCGR2B, NFKB1, TNF |
|  | Hepatic fibrosis/hepatic stellate cell activation | 8.32 × 10-11 | 1.10 × 10-1 | CXCL3, IL8, IL4R, CCR5, ICAM1, CD40, MYL6, IL10, IL6R, IL1B, IFNGR1, CCL5, NFKB1, TNF, CCR7, IL4 |
|  | IL-10 signaling | 3.82 × 10-9 | 1.41 × 10-1 | TRAF6, SOCS3, FOS, IL4R, CCR5, MAPK14, IL10, IL1B, FCGR2B, NFKB1, TNF |
|  | IL-12 signaling and production in macrophages | 6.87 × 10-9 | 8.97 × 10-2 | IL10, MAF, IFNGR1, NFKB1, IRF1, TRAF6, FOS, MAPK14, CD40, ZNF668, NOS2, TNF, PRKD3, IL4 |
|  | IL-17A signaling in gastric cells | 3.33 × 10-8 | 2.80 × 10-1 | IL8, FOS, MAPK14, CCL20, CCL5, NFKB1, TNF |
B | Role of cytokines in mediating communication between immune cells | 8.88 × 10-7 | 7.27 × 10-2 | IL8, IFNB1, IL13, IL4 |
|  | Communication between innate and adaptive immune cells | 6.73 × 10-6 | 3.67 × 10-2 | IL8, IFNB1, CCR7, IL4 |
|  | Airway inflammation in asthma | 1.81 × 10-5 | 3.33 × 10-1 | IL13, IL4 |
|  | Remodeling of epithelial adherens junctions | 1.08 × 10-4 | 4.41 × 10-2 | ACTR3, MAPRE1, CLIP1 |
|  | Prolactin signaling | 1.5 × 10-4 | 3.75 × 10-2 | SOCS3, FOS, IRF1 |