Phylogenetic relationship and virulence inference of Streptococcus Anginosus Group: curated annotation and whole-genome comparative analysis support distinct species designation

Table 5 Comparative summary of two component system (TCS) histidine kinases identified in SAG with other Streptococcus species

SAGTCS¹	Equivalent TCS HK in S. pneumoniae²	Gene name	Linked to virulence	SAG strain found in	Loci³	Best non-SAG BlastP results	PID⁴	Accession #
1	9	zmpSR	Yes	All SAG	SIR_0800	S. sanguinis	69	YP_001035081.1
2	5	ciaH	Yes	All SAG	SIR_0858	S. oralis	70	EGL88510.1
3	2	vicK	Yes	All SAG	SIR_0929	S. cristatus	84	ZP_08058686.1
4	None		ND^a	All SAG	SIR_1092	S. sanguinis	67	EGG40097.1
5	13	blpH	Yes	All SAG except SA^b SK1138, SA F0211 and SA SK52T	SIR_1152	S. equi	50	YP_002746951.1
6	1		Yes	All SAG	SIR_1196	S. cristatus	63	ZP_08059673.1
7	3		No	All SAG	SIR_1292	S. cristatus	67	ZP_08060583.1
8	None		ND	All SAG	SIR_1635	S. cristatus	89	ZP_07864009.1
9	8		Yes	All SAG	SIR_1771	S. mitis	64	ZP_07642266.1
10	12	comD	Yes	All SAG	SIR_1900	S. cristatus	59	ZP_08060066.1
11	6		Yes	SI^c and SA	SIR_0289	S. sanguinis	65	EGJ40992.1
12	7		Yes	SI and SA C1051	SIR_1062	S. cristatus	71	ZP_08060320.1
13	11		No	SI and SCC^d	SIR_1373	S. sanguinis	96	EGF13754.1
14	None		ND	SA C1051, SA 62CV and SA SK52T	SAIN_0922	S. oralis	95	ZP_13522336.1

¹Two component system histidine kinases systems found in SAG; ²The equivalent TCS found in S. pneumoniae as reviewed by Paterson et al. [74] , SAG orthologs found using blast hits from NCBI; ³All SAGTCS present in more than one SAG are listed using the loci from histidine kinase from SI B196 since this strain had the most TCS orthologs.; ⁴PID is equal to the percent aa identity for the best match using BlastP from NCBI ; ^aND; No data for this HK, ^bSA = S. anginosus, ^cSI = S. intermedius, ^dSCC = S. constellatus subsp. constellatus.

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