Table 2 Top biological and toxicological functions

Diseases and disorders

Cancer

5.96E-27 - 1.23E-03

733

Reproductive system disease

1.61E-16 - 1.19E-03

344

Dermatological diseases and conditions

3.42E-16 - 1.15E-03

282

Gastrointestinal disease

4.31E-13 - 8.26E-04

402

Endocrine system disorders

2.65E-10 - 7.46E-04

257

Molecular and cellular functions

Cellular movement

5.90E-18 - 1.43E-03

381

Cellular growth and proliferation

1.31E-10 - 1.12E-03

567

Cellular development

3.26E-09 - 1.07E-03

552

Cell-to-cell signaling and interaction

8.23E-09 - 1.48E-03

290

Cell death and survival

1.04E-08 - 1.48E-03

520

Physiological system development and function

Cardiovascular system development and function

9.52E-10 - 1.23E-03

271

Tumor morphology

6.48E-09 - 9.47E-04

140

Organismal development

9.59E-09 - 1.48E-03

371

Visual system development and function

1.34E-07 - 1.48E-03

98

Tissue development

2.59E-07 - 1.48E-03

350

Clinical chemistry and hematology

Decreased levels of albumin

1.63E-03 - 3.94E-01

6

Increased levels of alkaline phosphatase

2.79E-03 - 1.18E-01

16

Increased levels of creatinine

8.01E-03 - 8.01E-03

8

Increased levels of potassium

1.48E-02 - 5.41E-01

7

Increased levels of albumin

1.09E-01 - 2.21E-01

5

Cardiotoxicity

Cardiac stenosis

6.92E-04 - 3.13E-01

15

Congenital heart anomaly

3.64E-03 - 5.28E-01

23

Cardiac arteriopathy

4.20E-03 - 6.33E-01

42

Pulmonary hypertension

5.95E-03 - 1.18E-01

11

Cardiac hypertrophy

8.04E-03 - 1.00E00

51

Hepatotoxicity

Liver proliferation

2.37E-04 - 3.13E-01

39

Liver cholestasis

6.93E-04 - 5.84E-01

22

Liver cirrhosis

7.33E-04 - 2.21E-01

31

Liver damage

8.26E-04 - 2.21E-01

33

Liver hyperplasia/hyperproliferation

8.39E-03 - 5.03E-01

80

Nephrotoxicity

Renal proliferation

6.16E-06 - 2.21E-01

38

Renal damage

7.17E-04 - 5.03E-01

37

Renal tubule injury

7.17E-04 - 2.21E-01

24

Renal necrosis/cell death

1.84E-03 - 1.00E00

52

Renal inflammation

8.70E-03 - 1.00E00

34