RETRACTED ARTICLE: Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats

Table 2 Biologically relevant processes with enriched gene sets in the frontal cortical region

Biological process	Number of enriched gene sets related to the process	Direction
Protein synthesis and localization	21	⬇
Transmembrane transport	10	⬇
Nucleocytoplasmic transport	7	⬇
Cell growth	6	⬆⬇
Others	4	⬆⬇
Chromatine maintenance	3	⬇
Dendrite and synapse development	3	⬆
Oxidoreductase acitivity	2	⬇

This table summarizes the biological processes significantly altered in the frontal cortex (FC) of Dark Agouti (DA) rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The processes were created based on the network analysis of gene set enrichment (GSEA) analysis and individual considerations. All significantly enriched GO terms are included in one of the processes. Downward arrows represent down-, upward arrows represent upregulations. In some of the biological processes both up- and downregulated gene sets were present (mixed up- and downward arrows). See text for further details.

ISSN: 1471-2164