Skip to main content

Table 2 Biologically relevant processes with enriched gene sets in the frontal cortical region

From: RETRACTED ARTICLE: Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats

Biological process Number of enriched gene sets related to the process Direction
Protein synthesis and localization 21
Transmembrane transport 10
Nucleocytoplasmic transport 7
Cell growth 6 ⬆⬇
Others 4 ⬆⬇
Chromatine maintenance 3
Dendrite and synapse development 3
Oxidoreductase acitivity 2
  1. This table summarizes the biological processes significantly altered in the frontal cortex (FC) of Dark Agouti (DA) rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The processes were created based on the network analysis of gene set enrichment (GSEA) analysis and individual considerations. All significantly enriched GO terms are included in one of the processes. Downward arrows represent down-, upward arrows represent upregulations. In some of the biological processes both up- and downregulated gene sets were present (mixed up- and downward arrows). See text for further details.