Power to detect disease genes in simulated cases of locus heterogeneity. Estimated power to detect disease genes in the presence of locus heterogeneity when A) seven, three and one exomes share disease genes B) three, two and one exomes share disease genes C) ten and one exomes share disease genes D) each of four exomes results from a distinct disease gene. In each case gene p-values acquired using both Fisher's and Stouffer's methods are compared. Power is shown for raw p-values as well as Benjamini-Hochberg adjusted p-values. The height of each bar corresponds to the number of simulations in which the gene received a p-value or adjusted p-value < 0.05.