Skip to main content


Figure 4 | BMC Genomics

Figure 4

From: Identifying Mendelian disease genes with the Variant Effect Scoring Tool

Figure 4

Comparison of VEST score distribution for three empirical null models. Density plots created from VEST score distributions for three empirical null models representing neutral human missense variation. Null model mutations were filtered to remove overlap with the VEST training set, then scored with the VEST classifier. The Swissprot-based null shows an enrichment for large VEST scores in the right tail, indicating predicted functional mutations.

Back to article page