Figure 4From: Identifying Mendelian disease genes with the Variant Effect Scoring ToolComparison of VEST score distribution for three empirical null models. Density plots created from VEST score distributions for three empirical null models representing neutral human missense variation. Null model mutations were filtered to remove overlap with the VEST training set, then scored with the VEST classifier. The Swissprot-based null shows an enrichment for large VEST scores in the right tail, indicating predicted functional mutations.Back to article page